Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family of growth factors.
Previously, HB-EGF has been reported to be involved in diverse biological processes, including tumor formation, heart function,
wound healing, and eyelid formation. On the other hand, HB-EGF is widely expressed in the central nervous system, including the
hippocampus, cerebral cortex and cerebellum, and is considered to play pivotal roles in the development of the adult nervous system
and higher brain function. We generated mice in which HB-EGF activity is disrupted specifically in the ventral forebrain and
investigated the roles of HB-EGF in higher brain function. These knockout mice showed behavioral abnormalities such as an
increase in locomotor activity, decreased social interaction, a deficit of prepulse inhibition, and memory impairment. HB-EGF KO
mice also showed altered monoamine factors such as dopamine and serotonin, decreased spine density in neurons of the prefrontal
cortex, and impaired long-term potentiation (LTP) in the hippocampus. These results suggest that HB-EGF exerts significant
influence in higher brain functions, such as psychomotor behavior and memory formation and careful regulation of its activity will be
an important goal for treating a number of neurological diseases of the central nervous system.
雑誌書誌ID
AA1258935X
雑誌名
岐阜薬科大学紀要
雑誌名(英)
The annual proceedings of Gifu Pharmaceutical University
前脳選択的HB-EGF 欠損マウスを用いた、中枢神経系の高次脳機能におけるHB-EGF の役割
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前脳選択的HB-EGF 欠損マウスを用いた、中枢神経系の高次脳機能におけるHB-EGF の役割
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