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<Review>MET-88 : Sarcoplastic Reticulum Ca^<2+>-Uptake Stiumlator for Treating Chronic Heart Failure
https://gifu-pu.repo.nii.ac.jp/records/12042
https://gifu-pu.repo.nii.ac.jp/records/120421356fa43-6b8f-4b4b-b1c8-91f682803932
名前 / ファイル | ライセンス | アクション |
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KJ00000073927.pdf (745.4 kB)
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 2000-06-30 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | <Review>MET-88 : Sarcoplastic Reticulum Ca^<2+>-Uptake Stiumlator for Treating Chronic Heart Failure | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ページ属性 | ||||||
内容記述タイプ | Other | |||||
内容記述 | P(論文) | |||||
著者名(英) |
KURIMOTO, Tsukasa
× KURIMOTO, Tsukasa× ASAKA, Naomasa× MAEDA, Toshimatsu× IRIMURA, Kenji× MATSUURA, Naosuke |
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著者所属(日) | ||||||
値 | 大鵬薬品工業株式会社 製薬センター 薬理研究所/// | |||||
著者所属(英) | ||||||
言語 | en | |||||
値 | Sec of Pharmacology Research Lab. TOKUSHIMA RESEARCH CENTER TAIHO PHARMACEUTICAL CO., LTD./// | |||||
抄録(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | MET-88,an inhibitor of γ-butyrobetaine hydroxylase, can be characterized as a unique cardioprotective agent for the treatment of congestive heart failure (CHF) with an ability to regulate the activity of SR Ca^<2+>-ATPase. MET-88 protected the hypoxic and ischemic myocardium due to the modulation of myocardial metabolism and improved cardiac remodeling and hypertrophy as effectively as captopril. MET-88 also increased the failed Ca^<2+>-ATPase activity in the Sarcoplastic reticulum (SR), which increase might have resulted from ATP synthesis through glycolysis. These effects of MET-88 may be expected to improve mortality, prognosis, and exercise intolerance in CHF patients. In summary, MET-88 may be a useful drug for the treatment of CHF. | |||||
雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00053514 | |||||
書誌情報 |
岐阜藥科大學紀要 en : The annual proceedings of Gifu College of Pharmacy 巻 49, p. 45-52, 発行日 2000-06-30 |