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  1. 教員研究業績
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Iron regulatory protein 2 in ovarian endometrial cysts

https://gifu-pu.repo.nii.ac.jp/records/13459
https://gifu-pu.repo.nii.ac.jp/records/13459
20971969-635a-4c45-b92b-27932b46f174
Item type 会議発表論文 / Conference Paper(1)
公開日 2019-03-04
タイトル
タイトル Iron regulatory protein 2 in ovarian endometrial cysts
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_5794
資源タイプ conference paper
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Takenaka, Motoki

× Takenaka, Motoki

WEKO 21815

Takenaka, Motoki

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Suzuki, Noriko

× Suzuki, Noriko

WEKO 21816

Suzuki, Noriko

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Mori, Minako

× Mori, Minako

WEKO 21817

Mori, Minako

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Hirayama, Tasuku

× Hirayama, Tasuku

WEKO 21818

Hirayama, Tasuku

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Nagasawa, Hideko

× Nagasawa, Hideko

WEKO 21819

Nagasawa, Hideko

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Morishige, Ken-ichiro

× Morishige, Ken-ichiro

WEKO 21820

Morishige, Ken-ichiro

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抄録
内容記述タイプ Abstract
内容記述 Ovarian endometrial cysts cause some kinds of ovarian cancer, and iron is considered as one factor of carcinogenesis. In contrast, hypoxia is associated with progression, angiogenesis, metastasis, and resistance to therapy in cancer. We investigated hypoxia-induced perturbation of iron homeostasis in terms of labile iron, iron deposition, and iron regulatory protein (IRP) in ovarian endometrial cysts. Iron deposition, expression of IRPs, and a protein marker of hypoxia in human ovarian endometrial cysts were analyzed histologically. The concentration of free iron and the pO2 level of the cyst fluid of human ovarian cysts (n = 9) were measured. The expression of IRP2 under hypoxia was investigated in vitro by using Ishikawa cells as a model of endometrial cells. Iron deposition and the expression of IRP2 and Carbonic anhydrase 9 (CA9) were strong in endometrial stromal cells in the human ovarian endometrial cysts. The average concentration of free iron in the cyst fluid was 8.1 ± 2.9 mg/L, and the pO2 was 22.4 ± 5.2 mmHg. A cell-based study using Ishikawa cells revealed that IRP2 expression was decreased by an overload of Fe(II) under normoxia but remained unchanged under hypoxia even in the presence of excess Fe(II). An increase in the expression of IRP2 caused upregulation of intracellular iron as a result of the response to iron deficiency, whereas the protein was degraded under iron-rich conditions. We found that iron-rich regions existed in ovarian endometrial cysts concomitantly with the high level of IRP2 expression, which should generally be decomposed upon an overload of iron. We revealed that an insufficient level of oxygen in the cysts is the main factor for the unusual stabilization of IRP2 against iron-mediated degradation, which provides aberrant uptake of iron in ovarian endometrial stromal cells and can potentially lead to carcinogenesis.
書誌情報 en : Biochemical and Biophysical Research Communications

巻 487, 号 4, p. 789-794, 発行日 2017
ISSN
収録物識別子タイプ ISSN
収録物識別子 0006291X
DOI
識別子タイプ DOI
関連識別子 10.1016/j.bbrc.2017.04.115
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Cite as

Takenaka, Motoki, Suzuki, Noriko, Mori, Minako, Hirayama, Tasuku, Nagasawa, Hideko, Morishige, Ken-ichiro, 2017, Iron regulatory protein 2 in ovarian endometrial cysts: 789–794 p.

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