Royal jelly is one of many bee products and a secretion of worker honeybees. Worker honeybees feed the queen honeybee
for her life with only royal jelly. 10-Hydroxy-trans-2-decenoic acid (10H2DA) is the principal lipid component in royal jelly.
10-Hydroxydecanoic acid (10HDA) is also contained in royal jelly. These fatty acids have been reported to show several biological
activities, such as anti-tumor and estrogenic activity. Recently, we revealed the inhibitory effect of these fatty acids on innate immune
receptor signals. In this review, we focus on the biological activities of 10H2DA and 10HDA (especially immunomodulatory
activities). We also discuss the mechanisms underlying these biological activities and the possibilities for using these fatty acids as
lead compounds in new therapeutic drugs for immune disorders.
雑誌書誌ID
AA1258935X
雑誌名
岐阜薬科大学紀要
雑誌名(英)
The annual proceedings of Gifu Pharmaceutical University
自然免疫受容体シグナルに対するローヤルゼリー由来脂肪酸の抑制作用
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自然免疫受容体シグナルに対するローヤルゼリー由来脂肪酸の抑制作用
(548.42KB)
岐阜薬科大学学術リポジトリについて
