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<総説>ガスクロマトグラフィーにおける含フッ素カルボニル試薬の開発と応用 Deparment and Application of Fluorine-Containing Reagent in Gas Chromatography of Carbonyl Compounds 〓 小林, 恵子 河合, 聡 コバヤシ, ケイコ カワイ, サトシ KOBAYASHI, KEIKO KAWAI, SATOSHI P(論文) Pentafluorophenylhydrazine(PFPH)とO-(2,3,4,5,6-pentafluorobenzyl)-hydroxyl-amine(PFBOA)は水溶性低分子カルボニル化合物のガスクロマトグラフィー(GC)用縮合試薬としてすぐれた性質を有している。カルボニル化合物とPFPHあるいはPFBOAとの縮合反応は室温で速やかに進行し, 生成物は有機溶媒に容易に抽出され, 過剰の試薬は簡単に除去できる。誘導体は有機溶媒中で安定であり, 高い揮発性を有するため低温でのGC分離が可能であり, また電子捕捉検出器に高感度である。縮合反応によりsyn-, anti-異性体を形成するため2っのピークを与えるカルボニル化合物もある。PFPHに比べPFBOAの方がすぐれており, 誘導体化が短時間で進行し, 揮発性がより高いという利点,を持つ。PFPHとPFBOAはカルボニル化合物の微量分析に用いられている。 Pentafluorophenylhydrazine(PFPH) and O-(2,3,4,5,6-pentafluorobenzyl)-hydroxylamine (PFBOA) have been found to be excellent as a derivatizing agent in the gas chromatographic (GC) determination of low-molecular-weight carbonyl compounds in aqueous solution. The reaction of carbonyl compounds with PFPH or PFBOA proceeds readily at room temperature to yield derivatives extractable from the agueous solution with organic solvents, and the complete removal of the unreacted reagent is easily achieved. The resulting derivatives are stable in organic solvents and very volatile, and therefore the GC separation can be carried out at low temperatures. Also, the derivatives are extremely sensitive towards the electron capture detector. Some carbonyl compounds react with PFPH or PFBOA to show two peaks corresponding to syn- and anti- isomers resulting from condensation reactions with them. The utility of PFBOA is compared with that of PFPH. The formaton of the PFBOA-derivatives is much more easily achieved than that of the corresponding PFPH-derivatives. The PFBOA-derivatives are also much more volatile than the corresponding PFPH-derivatives, and therefore the GC separation can be carried out at lower temperature. PFPH and PFBOA have been applied to the micro-determination of various kinds of carbonyl compounds. 1983-06-03 jpn departmental bulletin paper https://gifu-pu.repo.nii.ac.jp/records/7304 AN00053514 岐阜藥科大學紀要 The annual proceedings of Gifu College of Pharmacy 32 15 19 https://gifu-pu.repo.nii.ac.jp/record/7304/files/KJ00000071546.pdf application/pdf 404.5 kB 1983-06-03