{"created":"2023-06-19T07:24:26.663969+00:00","id":10630,"links":{},"metadata":{"_buckets":{"deposit":"c89da94d-74a6-4452-9c5e-2db2121daaab"},"_deposit":{"created_by":5,"id":"10630","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"10630"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00010630","sets":["147:192"]},"author_link":["15608","15607","15609"],"item_1_alternative_title_5":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_alternative_title":"〓"}]},"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-06-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"30","bibliographicPageStart":"18","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"岐阜藥科大學紀要"},{"bibliographic_title":"The annual proceedings of Gifu College of Pharmacy","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"古川, 昭栄"}],"nameIdentifiers":[{"nameIdentifier":"15607","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"フルカワ, ショウエイ"}],"nameIdentifiers":[{"nameIdentifier":"15608","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"FURUKAWA, SHOEI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15609","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"前駆細胞から生じた未分化な神経細胞の分化を促し機能をもつ成熟神経細胞へと誘導する作用,神経機能を維持,調節する作用,神経細胞死を引き起こす外的,内的要因から神経細胞を保護する作用など,神経栄養因子は神経細胞の一生をコントロールする生体内成分である。近年,個々の神経細胞は多くの神経栄養因子の作用を受けること,個々の神経栄養因子は多種の神経細胞にオーバーラップして作用することがわかってきた。神経栄養因子は特定の時期や部位に整然と秩序だって発現することによって神経細胞に相加的,相乗的に作用を及ぼしていると考えられる。神経栄養因子にはアルツハイマー病,パーキンソン病,筋萎縮性側索硬化症などといった特定の神経細胞が選択的に死滅する神経疾患の予防や治療への応用が期待されている。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Neurotrophic factors (NTs) are endogenous molecules that exert effect on neurons throughout their lifespan. They stimulate neuronal differentiation of immature neurons and regulate neuronal functions of mature neurons such as protection from accidental neuronal death. Recent discoveries of new NTS differing from the nerve growth factor (NGF), a prototype of neurotrophic factors, provide indication that neurons respond to plural NTS Which function in various types of neurons. Ordered neurogenesis and neuronal regeneration proceed properly following the timely- and/or spatially-regulated expression of NTS and their receptors. The novel effects of NTS on neurons in neuronal disorders such as Alzheimer's disease, Perkinson's disease and amyotrophic lateral sclerosis showed qualify them for use in treating these disease.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053514","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Laboratory of Molecular Biology, Gifu Pharmaceutical University"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"岐阜薬科大学"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"1996-06-30"}],"displaytype":"detail","filename":"KJ00000073316.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"url":"https://gifu-pu.repo.nii.ac.jp/record/10630/files/KJ00000073316.pdf"},"version_id":"4b4cebf2-3c21-4389-b446-d78cc3b4e038"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<総説>神経栄養因子の機能と神経疾患","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<総説>神経栄養因子の機能と神経疾患"},{"subitem_title":"<Review>Neurotrophic Factors and Their Physiological Roles in Relation to Neurological Disorders.","subitem_title_language":"en"}]},"item_type_id":"1","owner":"5","path":["192"],"pubdate":{"attribute_name":"公開日","attribute_value":"1996-06-30"},"publish_date":"1996-06-30","publish_status":"0","recid":"10630","relation_version_is_last":true,"title":["<総説>神経栄養因子の機能と神経疾患"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2023-06-19T09:06:12.621351+00:00"}