{"created":"2023-06-19T07:24:32.786631+00:00","id":10776,"links":{},"metadata":{"_buckets":{"deposit":"bb96af34-9dfc-4c79-9a9d-a48a5738fcd1"},"_deposit":{"created_by":5,"id":"10776","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"10776"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00010776","sets":["147:193"]},"author_link":["15758","15757","15759"],"item_1_alternative_title_5":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_alternative_title":"〓"}]},"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-06-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"36","bibliographicPageStart":"24","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"岐阜藥科大學紀要"},{"bibliographic_title":"The annual proceedings of Gifu College of Pharmacy","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"渡辺, 昭彦"}],"nameIdentifiers":[{"nameIdentifier":"15757","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ワタナベ, アキヒコ"}],"nameIdentifiers":[{"nameIdentifier":"15758","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"WATANABE, AKIHIKO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"15759","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"側鎖にacetoxyamino基を有する一群のbenzonitrile化合物の中で最も強い抗アレルギー作用を有する3,5-bis(acetoxyacethylamino)-4-chloro-benzonitrile(以下, TYB-2285と称する)の免疫薬理学的な特性について紹介する。TYB-2285は, ラット受動皮膚アナフィラキシー(PCA)において1-30mg/kgで用量依存的な抑制作用を示し, 受動腹腔アナフィラキシー(PPA)において腹腔へのhistamine遊離を著明に抑制する。TYB-2285はIgE抗体で受動感作した腹腔マストセルをin vitroで抗原誘発して惹起したhistamine遊離を10-4Mでも抑制しない。TYB-2285はinterleukin-3(IL-3)でprimingしたマウス骨髄由来マストセル(Persistingce11; P-cell)からの抗原誘発によるhistamine遊離を抑制するが, IL-3無処置P-cellからの抗原誘発によるhistamine遊離を抑制しない。同様の結果はヒト末梢血好塩基球でも認められる。また, IL-3によるhistamine遊離の増強は抗CD11b抗体で抑制される。TYB-2285はヒト末梢血好酸球の培養ヒト血管内皮細胞への接着を濃度依存的に抑制するが, DSCGあるいはketotifenは生理的な濃度で抑制しない。TYB-2285は10-100mg/kgで用量依存的にラット気道への好酸球浸潤を抑制する。TYB-2285は抗原誘発によるラット即時型気道狭窄反応を3-30mg/kgで用量依存的に抑制し, ヒツジ自然感作喘息モデルにおいても抗原誘発後の投与により誘発6-8時間後の遅発型気道狭窄反応及び24時間後の気道過敏性を抑制する。TYB-2285は抗アレルギー作用に加えてT細胞依存性好酸球浸潤を抑制することから, 喘息治療薬としての可能性が期待される。その作用機序については, 主として細胞接着抑制作用に基づくものと考えられる。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Benzonitrile derivatives with acetoxyamino groups have strong anti-allergic actions. Among these compounds, 3,5-bis (acetoxyacethylaminoO -4-chrolo-benzonitrile (TYB-2285) is the strongest anti-allergic drug. In this review, immunopharmacological profile of TYB-2285 will be described. TYB-2285 inhibits passive cutaneous anaphylaxis at 1-30 mg/kg and also inhibits antigen-induced histamine release in passive peritoneal anaphylaxis. TYB-2285 does not inhibit antigen-induced histamine release from peritoneal mast cells passively sensitized with IgE even at 10-4 M. TYB-2285 inhibits antigen-induced histamine release from IL-3-primed persisting cells, but not from unprimed persisting cells. The same result was obtained in human basophils. The priming effect of IL-3 is inhibited by anti-CD1lb antibody. Adhesion of eosinophils to cultured human endothelial cells was inhibited by TYB-2285 and anti-VLA-4 antibody, but not by DSCG, ketotifen or anti-Mac-1 antibody. TYB-2285 inhibits antigen-induced accumulation of eosinophils into the airway of sensitized rats at 10-100 mg/kg. TYB-2285 inhibited acute bronchoconstriction in rats at 3-30 mg/kg. TYB-2285 inhibited late bronchoconstriction and airway hyperreactivity in allergic sheep when given after antigen provocation. These results, taken together, show that TYB-2285 is a promissing anti-asthmatic drug because of not only its anti-allergic effect, but also of its inhibitory effect on eosinophil accumulation. The mechanism of action of TYB-2285 is suggested to inhibit cell-cell adhesion.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053514","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Pharmaceuticals Research Center, Toyobo Co., Ltd. :(Present address)Institute of Allergy, Bayer Yakuhin Ltd."}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"東洋紡績株式会社医薬研究所:(現)バイエル薬品(株)アレルギー研究所"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"1997-06-30"}],"displaytype":"detail","filename":"KJ00000073462.pdf","filesize":[{"value":"765.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"url":"https://gifu-pu.repo.nii.ac.jp/record/10776/files/KJ00000073462.pdf"},"version_id":"e3d7d372-ec4a-4ba7-bc74-c31708083255"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<総説>Benzonitrile化合物の免疫薬理学的評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<総説>Benzonitrile化合物の免疫薬理学的評価"},{"subitem_title":"<Review>An immunopharmacological study of benzonitrile derivatives.","subitem_title_language":"en"}]},"item_type_id":"1","owner":"5","path":["193"],"pubdate":{"attribute_name":"公開日","attribute_value":"1997-06-30"},"publish_date":"1997-06-30","publish_status":"0","recid":"10776","relation_version_is_last":true,"title":["<総説>Benzonitrile化合物の免疫薬理学的評価"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2023-06-19T09:06:04.536224+00:00"}