@article{oai:gifu-pu.repo.nii.ac.jp:00010777,
 author = {IWAMURA, TATSUNORI and TSUTSUI, HISAYOSHI and KATAOKA, TADASHI and HORI, MIKIO and NIWA, MASAYUKI and NOZAKI, MASAKATSU},
 journal = {岐阜藥科大學紀要, The annual proceedings of Gifu College of Pharmacy},
 month = {Jun},
 note = {P(論文), In order to substantiate the hypothesis that the μ-, δ-, or κ-opioid receptor Affinity of opioid peptides can be elicited by an amino-terminus tyrosine residue and the 4th phenylalanine aromatic ring lying in the proper spatial disposition, a series of simple peptide-mimic tyrosine esters, in which tyrosine is linked to aromatic ring separated by a variety of methylene spacers, were prepared and evaluated by in vitro radioligand receptor assay. Compounds having the 6 or 7 methylene spacers were more potent in opioid receptor affinity than those having fewer or more methylene spacers. The N-monomethyl- and N, N-dimethyltyrosine congeners were more potent than the corresponding tyrosine esters. The order of the receptor type selectivity of these compounds was μ>>δ>κ.},
 pages = {37--46},
 title = {<Regular article>Opioid Receptor Affinities of Tyrosine ω-Phenylalkyl Esters, Simple Enkephalin Pharmacophore-mimics.},
 volume = {46},
 year = {1997}
}