{"created":"2023-06-19T07:24:32.828290+00:00","id":10777,"links":{},"metadata":{"_buckets":{"deposit":"fb7b6a72-7271-4353-8bbe-c20c19d33204"},"_deposit":{"created_by":5,"id":"10777","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"10777"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00010777","sets":["147:193"]},"author_link":["21314","21313","21287","23808","20983","23807"],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-06-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"46","bibliographicPageStart":"37","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"岐阜藥科大學紀要"},{"bibliographic_title":"The annual proceedings of Gifu College of Pharmacy","bibliographic_titleLang":"en"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"IWAMURA, TATSUNORI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"21287","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TSUTSUI, HISAYOSHI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23807","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KATAOKA, TADASHI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"20983","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HORI, MIKIO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"21314","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NIWA, MASAYUKI","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"23808","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NOZAKI, MASAKATSU","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"21313","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"In order to substantiate the hypothesis that the μ-, δ-, or κ-opioid receptor Affinity of opioid peptides can be elicited by an amino-terminus tyrosine residue and the 4th phenylalanine aromatic ring lying in the proper spatial disposition, a series of simple peptide-mimic tyrosine esters, in which tyrosine is linked to aromatic ring separated by a variety of methylene spacers, were prepared and evaluated by in vitro radioligand receptor assay. Compounds having the 6 or 7 methylene spacers were more potent in opioid receptor affinity than those having fewer or more methylene spacers. The N-monomethyl- and N, N-dimethyltyrosine congeners were more potent than the corresponding tyrosine esters. The order of the receptor type selectivity of these compounds was μ>>δ>κ.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053514","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Gifu Pharmaceutical University/Gifu Pharmaceutical University/Gifu Pharmaceutical University/Gifu Woman's University/Gifu University, School of Medicine/Gifu University, School of Medicine"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"岐阜薬科大学/岐阜薬科大学/岐阜薬科大学/岐阜女子大学/岐阜大学医学部/岐阜大学医学部"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"1997-06-30"}],"displaytype":"detail","filename":"KJ00000073463.pdf","filesize":[{"value":"568.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"url":"https://gifu-pu.repo.nii.ac.jp/record/10777/files/KJ00000073463.pdf"},"version_id":"bc4b2d2c-9dcc-4143-990f-af23d568c72e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<Regular article>Opioid Receptor Affinities of Tyrosine ω-Phenylalkyl Esters, Simple Enkephalin Pharmacophore-mimics.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<Regular article>Opioid Receptor Affinities of Tyrosine ω-Phenylalkyl Esters, Simple Enkephalin Pharmacophore-mimics.","subitem_title_language":"en"}]},"item_type_id":"1","owner":"5","path":["193"],"pubdate":{"attribute_name":"公開日","attribute_value":"1997-06-30"},"publish_date":"1997-06-30","publish_status":"0","recid":"10777","relation_version_is_last":true,"title":["<Regular article>Opioid Receptor Affinities of Tyrosine ω-Phenylalkyl Esters, Simple Enkephalin Pharmacophore-mimics."],"weko_creator_id":"5","weko_shared_id":5},"updated":"2023-06-19T08:35:23.511648+00:00"}