{"created":"2023-06-19T07:24:45.217680+00:00","id":11690,"links":{},"metadata":{"_buckets":{"deposit":"5942eb4c-274b-4fd8-8ee2-323a1b9e2739"},"_deposit":{"created_by":5,"id":"11690","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"11690"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00011690","sets":["147:195"]},"author_link":["16674","16673","16672"],"item_1_alternative_title_5":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_alternative_title":"〓"}]},"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-06-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"32","bibliographicPageStart":"21","bibliographicVolumeNumber":"48","bibliographic_titles":[{"bibliographic_title":"岐阜藥科大學紀要"},{"bibliographic_title":"The annual proceedings of Gifu College of Pharmacy","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石川, 正直"}],"nameIdentifiers":[{"nameIdentifier":"16672","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"イシカワ, マサナオ"}],"nameIdentifiers":[{"nameIdentifier":"16673","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ISHIKAWA, Masanao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16674","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"薬物の生体内の動きを厳重に制御することを目的とした薬物治療の理想であるドラッグデリバリーシステム(DDS)は,国内外を問わず,医薬品の開発研究の中でも最も活発な研究分野の一つである。DDSの基本設計には,リザーバー型とモノリティック(マトリックス)型の徐放性固形製剤があるが,前者の薬物放出の速度定数は外層の網目構造の大きさとその均一性によって定まるため,網目の目の形成方法としてどの様な技術を選択し,工夫するかが問題となる。本研究では,プラズマ照射高分子に生成する表面ラジカルのESRスペクトル研究から得られた基礎的知見をもとに選定した高分子粉末を外層にする薬物含有二重錠剤,あるいは,高分子コーティング顆粒を調製し,これらの錠剤や顆粒へのプラズマ照射により,多孔性外層に変換させた新規リザーバー型DDSを構築した。本DDS構築法は,完全乾式過程であるために残留溶媒の危倶がない等の特徴に加え,外層高分子の選択およびプラズマ照射条件の制御により,広範な目的・用途に適合する薬物放出制御型DDSの構築が可能である。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"A new controlled release drug delivery system (DDS) was established by oxygen plasma irradiation (radio-frequency discharge at 13.56 MHz) on the outermost layer of a doubly compressed tablet consisting of drug as core material and various polymers as wall material. Polymers were selected on the basis of effects of plasma irradiation dependent on polymer structure such as polyoxymethylene (POM), typically a plasma-degradable polymer, polystyrene (PST), a plasma-crosslinkable polymer, polycarbonate (PC), a bifunctional polymer having plasma-degradable and crosslinkable positions in the molecular structure, polybenzylmethacrylate (PBzMA) having a plasma-degradable main chain and plasma-crosslinkable functional group in the side chain and copolymer of methylmethacrylate (MMA) and benzylmethacrylate (BzMA). To expand applications of this DDS in various dosage forms, theophylline release was studied from plasma-irradiated polymer-coated granules. The present approach is superior to other methods for producing DDS, such as avoidance of direct plasma-exposure to a drug, being a totally dry process to eliminate any work up required in conventional wet processes, and a limited surface so that bulk properties of polymeric pharmaceutical aids are not affected.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053514","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Pharmaceutical and Analytical Research Laboratory, Central Research, Pfizer Pharmaceuticals"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"ファイザー製薬株式会社中央研究所 薬剤開発研究部 薬剤・分析研究室"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"1999-06-30"}],"displaytype":"detail","filename":"KJ00000073753.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"url":"https://gifu-pu.repo.nii.ac.jp/record/11690/files/KJ00000073753.pdf"},"version_id":"960cb2a3-c227-4c37-9c03-2407e70d8b7d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<総説>プラズマ照射を利用する新規なドラッグデリバリーシステムの設計と開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<総説>プラズマ照射を利用する新規なドラッグデリバリーシステムの設計と開発"},{"subitem_title":"<Review>Design and Development of New Drug Delivery System Using Plasma-Irradiated Pharmaceutical Aids","subitem_title_language":"en"}]},"item_type_id":"1","owner":"5","path":["195"],"pubdate":{"attribute_name":"公開日","attribute_value":"1999-06-30"},"publish_date":"1999-06-30","publish_status":"0","recid":"11690","relation_version_is_last":true,"title":["<総説>プラズマ照射を利用する新規なドラッグデリバリーシステムの設計と開発"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2023-06-19T09:05:44.095564+00:00"}