{"created":"2023-06-19T07:24:45.260118+00:00","id":11691,"links":{},"metadata":{"_buckets":{"deposit":"9243e0af-519e-4423-94d4-58bb76b27aca"},"_deposit":{"created_by":5,"id":"11691","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"11691"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00011691","sets":["147:195"]},"author_link":["16677","16676","18101","18097","16675","18093"],"item_1_alternative_title_5":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_alternative_title":"〓"}]},"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-06-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"42","bibliographicPageStart":"33","bibliographicVolumeNumber":"48","bibliographic_titles":[{"bibliographic_title":"岐阜藥科大學紀要"},{"bibliographic_title":"The annual proceedings of Gifu College of Pharmacy","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"甲木, 由紀夫"}],"nameIdentifiers":[{"nameIdentifier":"16675","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野, 和行"}],"nameIdentifiers":[{"nameIdentifier":"18093","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"カツキ, ユキオ"}],"nameIdentifiers":[{"nameIdentifier":"16676","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ヒラノ, カズユキ"}],"nameIdentifiers":[{"nameIdentifier":"18097","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KATSUKI, Yukio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"16677","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HIRANO, Kazuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18101","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"ジエノゲスト(Dienogest)は,合成ステロイド剤の一つであり,経口投与にてprogesterone様作用を現わすことから,estrogen依存性疾患に対する効果が期待され,子宮内膜症治療薬として現在臨床試験中である。本研究における動物実験の結果,dienogestの主たるホルモン作用はprogesterone様作用であるものの,本作用はprogesterone受容体拮抗薬RU486存在下においても発現することから,作用発現様式の点で他のprogestinsと異なることが示唆された。また,ラットの実験的子宮内膜症モデルにおいて,内膜症組織に対する治療効果を示したのに加え,腹腔内免疫環境の改善ならびに骨量の維持など既存薬の作用を上回る特徴も認められた。さらに,本剤は,medeoxyprogesterone acetateおよびdanazolに比し,サルに長期投与しても血栓症発症のリスクが少なかった。この結果,dienogestが子宮内膜症治療薬として,高い有効性と安全性を併せ持った薬剤となる可能性が明らかとなった。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Dienogest is an orally active synthetic steroid with prominent progestational activity. It is thus being evaluated clinically for treatment of endometriosis, an estrogen-dependent disease. The drug was found to differ from other progestins in mechanism of action on progesterone receptor since progestational activity did not disappear in the presence of RU486,a progesterone receptor antagonist. Dienogest showed therapeutic effect in rats with experimental endometriosis as well as ameriolation of endometrial implant-induced alteration in the intraperitoneal immune system and maintenance of bone mineral density, compared to commonly used drugs for endometriosis. A Iong-term treatment resulted in lower risk of thrombosis than medroxyprogesterone acetate or danazol in monkeys. Dienogest should thus serve as a highly safe potent agent for treating of endometriosis.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053514","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Research Center, Mochida Pharmaceutical Co., Ltd./Laboratory of Pharmaceutics, Gifu Pharmaceutical University"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"持田製薬株式会社総合研究所/岐阜薬科大学"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"1999-06-30"}],"displaytype":"detail","filename":"KJ00000073754.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"url":"https://gifu-pu.repo.nii.ac.jp/record/11691/files/KJ00000073754.pdf"},"version_id":"33eeb646-48fd-4065-97f9-9daa7c7dc7f9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<総説>合成ステロイド剤ジエノゲストの作用機序に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<総説>合成ステロイド剤ジエノゲストの作用機序に関する研究"},{"subitem_title":"<Review>Mechanism of the Action of Dienogest, a Synthetic Steroid","subitem_title_language":"en"}]},"item_type_id":"1","owner":"5","path":["195"],"pubdate":{"attribute_name":"公開日","attribute_value":"1999-06-30"},"publish_date":"1999-06-30","publish_status":"0","recid":"11691","relation_version_is_last":true,"title":["<総説>合成ステロイド剤ジエノゲストの作用機序に関する研究"],"weko_creator_id":"5","weko_shared_id":5},"updated":"2023-06-19T08:40:58.069132+00:00"}