{"created":"2023-06-19T07:24:52.437607+00:00","id":12040,"links":{},"metadata":{"_buckets":{"deposit":"5085f442-b04d-4c5c-a45f-ff00437f16a6"},"_deposit":{"created_by":5,"id":"12040","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"12040"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00012040","sets":["147:196"]},"author_link":["17021","17022","17020"],"item_1_alternative_title_5":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_alternative_title":"〓"}]},"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-06-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"32","bibliographicPageStart":"23","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"岐阜藥科大學紀要"},{"bibliographic_title":"The annual proceedings of Gifu College of Pharmacy","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山本, 浩充"}],"nameIdentifiers":[{"nameIdentifier":"17020","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ヤマモト, ヒロミツ"}],"nameIdentifiers":[{"nameIdentifier":"17021","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamamoto, Hiromitsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"17022","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"本総説ではペプチドの経粘膜投与DDS製剤の最近の動向を概説するとともに,我々が開発した微粒子製剤について紹介する。生分解性微粒子として,リン脂質から成るリボソーム,ポリ乳酸グリコール酸等の高分子から成るナノスフェアを取り上げた。これらの微粒子キャリアの表面を粘膜付着性高分子で修飾することで粘膜付着性を賦与し,吸収部位滞留性を向上させた。これにインスリンやカルシトニンを封入した経口投与製剤及び経肺投与製剤を開発した。キトサンで修飾した本製剤を,ラットに経口投与したところ,その粘膜付着性により溶液投与群,未修飾粒子投与群に比べ有意に薬理効果が持続した。また,ナノスフェアをネブライザーで噴霧しモルモットに経肺投与した結果,ナノスフェアが肺深部に沈着することにより,溶液投与群に比べ薬理効果が有意に持続した。これらの研究成果により,これまで困難とされてきたペプチドの経粘膜投与が可能なことを示した。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"In this review, the recent topics of mucosal peptide delivery systems are overviewed. Furthermore, biodegradable microparticulate dosage forms developed by us are introduced. Phospholipid liposomes and nanospheres of biodegradable polymer were designed. Mucoadhesive microparticulate dosage forms were prepared by the surface modification of these drug carriers with a mucoadhesive polymer to prolong their residence time at the absorption site. Oral and pulmonary delivery systems with insulin or a calcitonin loaded microparticulate system were devised. Oral administration of peptide encapsulated microparticulate systems modified with chitosan to a rat significantly prolonged the pharmacological effects due to their mucoadhesive properties when compared with drug solution and non-modified microparticulate systems. After pulmonary administration of aerosolized nanosphere with a nebulizer to a guinea pig, the biological effects were more prolonged than with a drug solution due to the deep and homogenous deposition of nanospheres into the lung. These findings suggested the possibilities of mucosal delivery. Of peptide which is poorly absorbed via mucosa, by using biodegradable microparticulate dosage forms developed by us.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053514","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"岐阜薬科大学"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2000-06-30"}],"displaytype":"detail","filename":"KJ00000073925.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"url":"https://gifu-pu.repo.nii.ac.jp/record/12040/files/KJ00000073925.pdf"},"version_id":"bd8afac1-a376-42a4-89de-a71bf8dc7ec4"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<総説>ペプチドの経粘膜投与を目指した生分解性微粒子製剤の設計","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<総説>ペプチドの経粘膜投与を目指した生分解性微粒子製剤の設計"},{"subitem_title":"<Review>Design of Biodegradable Microparticulate Dosage Forms for Mucosal Peptide Delivery","subitem_title_language":"en"}]},"item_type_id":"1","owner":"5","path":["196"],"pubdate":{"attribute_name":"公開日","attribute_value":"2000-06-30"},"publish_date":"2000-06-30","publish_status":"0","recid":"12040","relation_version_is_last":true,"title":["<総説>ペプチドの経粘膜投与を目指した生分解性微粒子製剤の設計"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2023-06-19T09:05:33.671040+00:00"}