{"created":"2023-06-19T07:24:57.835342+00:00","id":12168,"links":{},"metadata":{"_buckets":{"deposit":"41ce7589-4fb2-426a-8cbe-13fd5950c7ea"},"_deposit":{"created_by":5,"id":"12168","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"12168"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00012168","sets":["147:197"]},"author_link":["22117","22124","17157","17924","22120","22127","22121","22118","17156","22116","22115","17747","22119","22122","22126","22123","22125","17158"],"item_1_alternative_title_5":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_alternative_title":"〓"}]},"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-06-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"65","bibliographicPageStart":"61","bibliographicVolumeNumber":"50","bibliographic_titles":[{"bibliographic_title":"岐阜藥科大學紀要"},{"bibliographic_title":"The annual proceedings of Gifu College of Pharmacy","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"恋田, 和憲"}],"nameIdentifiers":[{"nameIdentifier":"17156","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今村, 仁"}],"nameIdentifiers":[{"nameIdentifier":"22115","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森本, 宏治"}],"nameIdentifiers":[{"nameIdentifier":"22116","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋本, 圭二"}],"nameIdentifiers":[{"nameIdentifier":"22117","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河合, 聡"}],"nameIdentifiers":[{"nameIdentifier":"22118","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宇野, 文二"}],"nameIdentifiers":[{"nameIdentifier":"17747","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"コイダ, カズノリ"}],"nameIdentifiers":[{"nameIdentifier":"17157","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"イマムラ, ヒトシ"}],"nameIdentifiers":[{"nameIdentifier":"22119","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"モリモト, コウジ"}],"nameIdentifiers":[{"nameIdentifier":"22120","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ハシモト, ケイジ"}],"nameIdentifiers":[{"nameIdentifier":"22121","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"カワイ, サトシ"}],"nameIdentifiers":[{"nameIdentifier":"22122","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ウノ, ブンジ"}],"nameIdentifiers":[{"nameIdentifier":"22123","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KOIDA, Kazunori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"17158","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"IMAMURA, Hitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22124","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MORIMOTO, Kouji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22125","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HASHIMOTO, Keiji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22126","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KAWAI, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"22127","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uno, Bunji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"17924","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"Melatoninおよびその関連化合物のtrifluoroacetyl(TFA)化反応によって生成する3,3-spirocyclicインドール誘導体の生成機構を考察した。Melatonin,melatonin-(N-acetyl)-d_3,serotonin類およびtryptamine類のTFA誘導体のマススペクトルの測定とその解析より,この特異的な誘導体化反応は側鎖にエノール化しうるN-acyl基をもつN-acyltryptamine類に共通して起こる閉環反応であることを明らかにした。そして,インドール骨格のN-TFA化による3位の活性化と側鎖のN-acyl基のエノール化を経てspirocyclic構造生成に至るmelatoninのTFA誘導体反応の生成機構が提唱された。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"The trifluoroacetylation (TFA) mechanism of melatonin was extensively discussed on the basis of mass spectral data for the TFA derivatives of melatonin, melatonin-(N-acetyl)-d_3,serotonins, and tryptamines. It has been demonstrated that 3,3-spirocyclic indole derivatives are commonly generated in the TFA reactions of N-acyltryptamines of the enolic form. We have proposed a mechanism where the specific cyclization reaction involving the spirocyclic structure proceeds by virtue of activation of the 3-position of the indole moiety induced by TFA of the N atom in the moiety and enolation of the N-acyl group.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053514","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Laboratory of Pharmaceutical Analytical Chemistry, Gifu Pharmaceutical University/Laboratory of Pharmaceutical Analytical Chemistry, Gifu Pharmaceutical University/Laboratory of Pharmaceutical Analytical Chemistry, Gifu Pharmaceutical University/Kyoto Pharmaceutical University/Laboratory of Pharmaceutical Analytical Chemistry, Gifu Pharmaceutical University/Laboratory of Pharmaceutical Analytical Chemistry, Gifu Pharmaceutical University"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"岐阜薬科大学/岐阜薬科大学/岐阜薬科大学/京都薬科大学/岐阜薬科大学/岐阜薬科大学"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2001-06-30"}],"displaytype":"detail","filename":"KJ00000074073.pdf","filesize":[{"value":"396.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"url":"https://gifu-pu.repo.nii.ac.jp/record/12168/files/KJ00000074073.pdf"},"version_id":"54eb1702-6f32-468b-a45b-793b1863db5f"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<一般論文>Melatoninのtrifluoroacetyl誘導体の生成機構に関する考察","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<一般論文>Melatoninのtrifluoroacetyl誘導体の生成機構に関する考察"},{"subitem_title":"<Regular Article>Mechanistic Study on Generation of the Trifluoroacetyl Derivative of Melatonin","subitem_title_language":"en"}]},"item_type_id":"1","owner":"5","path":["197"],"pubdate":{"attribute_name":"公開日","attribute_value":"2001-06-30"},"publish_date":"2001-06-30","publish_status":"0","recid":"12168","relation_version_is_last":true,"title":["<一般論文>Melatoninのtrifluoroacetyl誘導体の生成機構に関する考察"],"weko_creator_id":"5","weko_shared_id":5},"updated":"2023-06-19T08:47:01.888107+00:00"}