{"created":"2023-06-19T07:25:09.692407+00:00","id":12740,"links":{},"metadata":{"_buckets":{"deposit":"85022ac8-39a4-49ad-8a22-5787384e9c52"},"_deposit":{"created_by":5,"id":"12740","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"12740"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00012740","sets":["147:199"]},"author_link":["13081","17738","8870","13080","17736","17737"],"item_1_alternative_title_5":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_alternative_title":"〓"}]},"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-06-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"20","bibliographicPageStart":"11","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"岐阜藥科大學紀要"},{"bibliographic_title":"The annual proceedings of Gifu College of Pharmacy","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊藤, 幸祐"}],"nameIdentifiers":[{"nameIdentifier":"17736","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"葛谷, 昌之"}],"nameIdentifiers":[{"nameIdentifier":"13080","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"イトウ, コウスケ"}],"nameIdentifiers":[{"nameIdentifier":"17737","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"クズヤ, マサユキ"}],"nameIdentifiers":[{"nameIdentifier":"13081","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ITO, Kousuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"17738","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KUZUYA, Masayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8870","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"今日,薬物療法の最適化を目指してドラッグデリバリーシステム(DDS)の研究が多方面にわたり活発に展開されている。なかでも,経口製剤における薬物放出制御技術は,投与の簡便さや適用範囲の広さなどの面から重要な位置付けをもつ分野の一つである。さらに最近では,より合理的な経口治療を可能にするための高度な放出技術に関する研究開発が進んでいる。また,我々の教室ではプラズマ表面処理の分子機構の解明とともに,その医薬学的応用を意図した研究を行ってきており,その応用研究の一つとして完全ドライプロセスによる新規DDSについて報告している。本研究では,これらの応用研究の一環として,核錠にテオフィリンを用い,実際に医薬品添加物などに用いられている高分子を外層に用いた二重錠剤へのアルゴンプラズマ照射により,長いラグタイムの後速やかに薬物を放出する遅延型速放錠をはじめとする様々な薬物放出挙動を持つ二重錠剤の構築に成功した。また,プラズマ照射による効果はプラズマ反応装置をはじめとする様々なファクターにより影響を受けることが知られている。そこで,プラズマ照射イノシトールの表面ラジカルのESRスペクトル解析による簡便な化学的プラズマ診断法を検討した。その結果,プラズマ診断法の一つとしての\"スピンプローブ法\"の有効性が確認された。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"For the most suitable therapy, a wide variety of approaches of a controlled-release system have been thus far investigated for oral application. Of these approaches, preparations of controlled-release systems have been noted as orally applicable delivery systems. On the basis of findings from a series of fundamental studies on elucidation of the structures of plasma-induced radicals formed on a variety of polymers by electron spin resonance (ESR) with the aid of systematic computer simulations, we have reported that sustained-release tablets applicable for drug delivery system (DDS) can be prepared by oxygen plasma-irradiation on the outermost layer of a double-compressed tablet which consists of a drug as the core material and various types of polymers as the wall material. In this contribution, we report on the study of the possibility of a rapid-release tablet being converted into a time controlled-release tablet in an experiment using argon plasma-irradiation on multilayered tablets composed of theophylline as the core model drug and various polymeric pharmaceutical aids as the wall material. We must consider various operational and system-dependent parameters for plasma treatment. We examined developing a method to deduce the plasma power useful for experimental and practical design of plasma treatment.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053514","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Laboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University/Laboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"岐阜薬科大学薬品物理化学教室/岐阜薬科大学薬品物理化学教室"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2003-06-30"}],"displaytype":"detail","filename":"KJ00000074421.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00000074421","url":"https://gifu-pu.repo.nii.ac.jp/record/12740/files/KJ00000074421.pdf"},"version_id":"e8c5fc01-ce7a-4828-a928-aad447dfb9ec"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ドラッグデリバリーシステム(DDS)","subitem_subject_scheme":"Other"},{"subitem_subject":"薬物放出制御","subitem_subject_scheme":"Other"},{"subitem_subject":"二重錠剤","subitem_subject_scheme":"Other"},{"subitem_subject":"アルゴンプラズマ照射","subitem_subject_scheme":"Other"},{"subitem_subject":"電子スピン共鳴(ESR)","subitem_subject_scheme":"Other"},{"subitem_subject":"プラズマ診断","subitem_subject_scheme":"Other"},{"subitem_subject":"drug delivery system (DDS)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"controlled-release","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"double-compressed tablet","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"argon plasma-irradiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"electron spin resonance (ESR)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"plasma diagnosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<総説>低温プラズマ技術によるDDSの薬物放出制御の設計と開発に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<総説>低温プラズマ技術によるDDSの薬物放出制御の設計と開発に関する研究"},{"subitem_title":"<Review>Design and Development of Controlled-Release Using Plasma Technology","subitem_title_language":"en"}]},"item_type_id":"1","owner":"5","path":["199"],"pubdate":{"attribute_name":"公開日","attribute_value":"2003-06-30"},"publish_date":"2003-06-30","publish_status":"0","recid":"12740","relation_version_is_last":true,"title":["<総説>低温プラズマ技術によるDDSの薬物放出制御の設計と開発に関する研究"],"weko_creator_id":"5","weko_shared_id":5},"updated":"2023-06-19T08:51:02.339628+00:00"}