{"created":"2023-06-19T07:25:09.775927+00:00","id":12742,"links":{},"metadata":{"_buckets":{"deposit":"6e18aee6-dbed-4e1c-94d7-4f0c257a27dd"},"_deposit":{"created_by":5,"id":"12742","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"12742"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00012742","sets":["147:199"]},"author_link":["17743","17744","17742"],"item_1_alternative_title_5":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_alternative_title":"〓"}]},"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-06-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"42","bibliographicPageStart":"31","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"岐阜藥科大學紀要"},{"bibliographic_title":"The annual proceedings of Gifu College of Pharmacy","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大宮, 誠"}],"nameIdentifiers":[{"nameIdentifier":"17742","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"オオミヤ, マコト"}],"nameIdentifiers":[{"nameIdentifier":"17743","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"OHMIYA, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"17744","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"脳神経系の形成過程を分子レベルで解明し,神経疾患の病態の理解,治療法の開発に生かすことは神経科学研究の大きな目標のひとつである.神経栄養因子は脳の形成過程で重要な役割を果たすと推定されているが,実際には培養系を用いた断片的な知見しか得られていないのが現状である.成熟脳にも神経幹細胞が見いだされ,その臨床応用が視野に入った現在,神経幹細胞から神経細胞へと至る道筋に神経栄養因子がどのような役割を果たすのかを解明することは大きな意義があると考えている.本研究では大脳皮質形成過程に着目し,特に生体系での実験を中心に脳の形成過程に及ぼす神経栄養因子の役割について検討した.本研究結果から水頭症をはじめとする先天性の脳形成異常疾患に神経栄養因子の発現異常が関与している可能性が示唆された.ならびに正常な大脳皮質の発達には秩序だった神経栄養因子の発現が密接に関わっていることも明らかにした.","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Elucidation of molecular mechanisms and cellular processes during development of the nervous system is one of the major targets of neuroscience, because of merit for understanding or treatment of neurological diseases. Neurotrophic factors are thought to play a vital role during the course of constructing the cerebral cortex, but their actual functions in vivo remain unknown except for patchy findings obtained from in vitro experiments. Recently, neural stem cells have been found even in the mature brain, and their activation or proper differentiation is now expected to be useful for the clinical treatment of neurological diseases with neuronal loss such as Parkinson's disease or Alzheimer's disease. This encouraged us to investigate the effects of neurotrophic factors on neural stem cells. Ln the present study, we focused on the effects of neurotrophic factors on the developing rodent cerebral cortex, especially using in vivo experimental techniques. The obtained results suggest that abnormal expression of particular neurotrophic factors is responsible for brain malformation including hydrocephalus, and that timely- and spatially-regulated expression of neurotrophic factors is important in normal development of the cerebral cortex.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00053514","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Cardiovascular Diseases Research Pharmacology Labs., Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd."}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"山之内製薬(株)創薬研究本部 薬理研究所 薬理第二研究室"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2003-06-30"}],"displaytype":"detail","filename":"KJ00000074423.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00000074423","url":"https://gifu-pu.repo.nii.ac.jp/record/12742/files/KJ00000074423.pdf"},"version_id":"038b8f0e-574f-4b84-a8b0-a71cff865dd5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"神経栄養因子","subitem_subject_scheme":"Other"},{"subitem_subject":"大脳皮質","subitem_subject_scheme":"Other"},{"subitem_subject":"水頭症","subitem_subject_scheme":"Other"},{"subitem_subject":"塩基性繊維芽細胞成長因子","subitem_subject_scheme":"Other"},{"subitem_subject":"脳由来神経栄養因子","subitem_subject_scheme":"Other"},{"subitem_subject":"neurotrophic factors","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cerebral cortex","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hydrocephalus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"FGF-2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"BDNF","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<総説>大脳皮質構築過程における神経栄養因子の役割に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<総説>大脳皮質構築過程における神経栄養因子の役割に関する研究"},{"subitem_title":"<Review>Roles of neurotrophic factors for the development of the rodent cerebral cortex","subitem_title_language":"en"}]},"item_type_id":"1","owner":"5","path":["199"],"pubdate":{"attribute_name":"公開日","attribute_value":"2003-06-30"},"publish_date":"2003-06-30","publish_status":"0","recid":"12742","relation_version_is_last":true,"title":["<総説>大脳皮質構築過程における神経栄養因子の役割に関する研究"],"weko_creator_id":"5","weko_shared_id":5},"updated":"2023-06-19T08:51:00.492299+00:00"}