{"_buckets": {"deposit": "1c4800d0-c1f0-4751-be4d-328334b001c6"}, "_deposit": {"created_by": 5, "id": "12786", "owners": [5], "pid": {"revision_id": 0, "type": "depid", "value": "12786"}, "status": "published"}, "_oai": {"id": "oai:gifu-pu.repo.nii.ac.jp:00012786", "sets": ["201"]}, "author_link": ["17826", "17829", "17815", "17824", "17817", "17819", "17821", "17823", "17822", "17825", "17818", "17816", "17828", "17827", "17820"], "item_1_biblio_info_14": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2005-06-30", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "50", "bibliographicPageStart": "45", "bibliographicVolumeNumber": "54", "bibliographic_titles": [{"bibliographic_title": "岐阜藥科大學紀要"}, {"bibliographic_title": "The annual proceedings of Gifu College of Pharmacy", "bibliographic_titleLang": "en"}]}]}, "item_1_creator_6": {"attribute_name": "著者名(日)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "岩村, 樹憲"}], "nameIdentifiers": [{"nameIdentifier": "17815", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "上澤, 佳之"}], "nameIdentifiers": [{"nameIdentifier": "17816", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "片岡, 貞"}], "nameIdentifiers": [{"nameIdentifier": "17817", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "徳山, 尚吾"}], "nameIdentifiers": [{"nameIdentifier": "17818", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "植田, 弘師"}], "nameIdentifiers": [{"nameIdentifier": "17819", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_creator_7": {"attribute_name": "著者名よみ", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "イワムラ, タツノリ"}], "nameIdentifiers": [{"nameIdentifier": "17820", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ウエサワ, ヨシユキ"}], "nameIdentifiers": [{"nameIdentifier": "17821", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "カタオカ, タダシ"}], "nameIdentifiers": [{"nameIdentifier": "17822", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "トクヤマ, ショウゴ"}], "nameIdentifiers": [{"nameIdentifier": "17823", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ウエダ, ヒロシ"}], "nameIdentifiers": [{"nameIdentifier": "17824", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_creator_8": {"attribute_name": "著者名(英)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "IWAMURA, Tatsunori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "17825", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "UESAWA, Yoshiyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "17826", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KATAOKA, Tadashi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "17827", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TOKUYAMA, Shogo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "17828", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "UEDA, Hiroshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "17829", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_description_1": {"attribute_name": "ページ属性", "attribute_value_mlt": [{"subitem_description": "P(論文)", "subitem_description_type": "Other"}]}, "item_1_description_11": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "モルヒネをはじめとするいくつかのオピオイド鎮痛薬、合成したオピオイド様化合物の腫瘍細胞増殖抑制作用について調べた。腫瘍細胞として、A549(扁平上皮肺がん細胞)、N417(小細胞肺がん細胞)、MCF-7(乳がん細胞)およびKATO III(胃がん細胞)を試験に用いた。市販のオピオイド鎮痛薬ブプレノルフィンは、A549細胞に対してアポトーシス小体、DNAの断片化とDNAラダーの発現を伴うアポトーシス死を引き起こした。合成したオピオイド様化合物(100μM)について、A549細胞に対する細胞増殖抑制作用をalamar blue染色法により検討した。ブプレノルフィンと同様のエテノモルヒネ構造を有するPEO(8c)およびH_2-PEO (14c)は強い細胞増殖抑制効果(100%近い)を示した。一方、ピペリジン骨格のfentanylおよびmeperidineはむしろ細胞増殖を活性化した。A549細胞の生存活性に対する主な試験化合物のIC_\u003c50\u003e値はそれぞれ、buprenorphine = 38.0μM, PEG (8c) = 73.8μMならびにloperamide = 3,7μMであった。", "subitem_description_type": "Other"}]}, "item_1_description_12": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "We examined the effects of opioid analgesics and synthetic opioid analogues on the proliferation of human cancer cells. Cell lines used were A549 (squamous epithelial cells of lung cancer), N417 (small cells of lung cancer), MCF-7 (breast cancer) and KATO III (stomach cancer). We found buprenorphine, a commercially available analgesic, induced apoptotic cell death on A549 cells in the appearance of the apoptotic body, nuclear fragmentation and DNA laddering. Cytostatic activity of synthetic opioid analogues was also evaluated at 100μM by alamar blue assay on the A549 cell line. PEO (8c) and H_2-PEO (14c) which had an ethenomorphine structure the same as buprenorhine, showed potent inhibition (by 100%) of the cell growth, however fentanyl and meperidine which had a piperidine molecular frame, enhanced the cell proliferation. The IC_\u003c50\u003e values of the compounds on the survival activity of A549 cells were 38.0μM (buprenorphine), 73.8μM (PEG, 8c), and 3.7μM (loperamide).", "subitem_description_type": "Other"}]}, "item_1_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00053514", "subitem_source_identifier_type": "NCID"}]}, "item_1_text_10": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Laboratory of Pharmaceutical Chemistry, Gifu Pharmaceutical University"}, {"subitem_text_language": "en", "subitem_text_value": "Laboratory of Pharmaceutical Chemistry, Gifu Pharmaceutical University"}, {"subitem_text_language": "en", "subitem_text_value": "Laboratory of Pharmaceutical Chemistry, Gifu Pharmaceutical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Molecular Pharmacology, Nagasaki University School of Pharmaceutical Sciences"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Molecular Pharmacology, Nagasaki University School of Pharmaceutical Sciences"}]}, "item_1_text_2": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_text_value": "一般論文"}]}, "item_1_text_3": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Article"}]}, "item_1_text_9": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "岐阜薬科大学薬化学講座"}, {"subitem_text_value": "岐阜薬科大学薬化学講座"}, {"subitem_text_value": "岐阜薬科大学薬化学講座"}, {"subitem_text_value": "長崎大学薬学部分子薬理学分野"}, {"subitem_text_value": "長崎大学薬学部分子薬理学分野"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2005-06-30"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00004170373.pdf", "filesize": [{"value": "689.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 689600.0, "url": {"url": "https://gifu-pu.repo.nii.ac.jp/record/12786/files/KJ00004170373.pdf"}, "version_id": "8e6f16b7-ffed-4f88-b2b9-0c827365229a"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "モルヒネ", "subitem_subject_scheme": "Other"}, {"subitem_subject": "エテノモルヒネ", "subitem_subject_scheme": "Other"}, {"subitem_subject": "麻薬性鎮痛薬", "subitem_subject_scheme": "Other"}, {"subitem_subject": "アポトーシス", "subitem_subject_scheme": "Other"}, {"subitem_subject": "細胞増殖抑制作用", "subitem_subject_scheme": "Other"}, {"subitem_subject": "抗腫瘍活性", "subitem_subject_scheme": "Other"}, {"subitem_subject": "morphine", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ethenomorphine", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "narcotic analgesics", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "apoptosis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cytostatic activity", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "anticancer activity", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "6,14-Ethenomorphine類の合成と腫瘍細胞増殖抑制作用", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "6,14-Ethenomorphine類の合成と腫瘍細胞増殖抑制作用"}, {"subitem_title": "Synthesis of 6,14-ethenomorphines and the Cytostatic Activity for Tumor Cells", "subitem_title_language": "en"}]}, "item_type_id": "1", "owner": "5", "path": ["201"], "permalink_uri": "https://gifu-pu.repo.nii.ac.jp/records/12786", "pubdate": {"attribute_name": "公開日", "attribute_value": "2005-06-30"}, "publish_date": "2005-06-30", "publish_status": "0", "recid": "12786", "relation": {}, "relation_version_is_last": true, "title": ["6,14-Ethenomorphine類の合成と腫瘍細胞増殖抑制作用"], "weko_shared_id": -1}