{"created":"2023-06-19T07:25:15.395022+00:00","id":12915,"links":{},"metadata":{"_buckets":{"deposit":"fbc159d5-01f0-460e-81e3-66e2115d22a8"},"_deposit":{"created_by":4,"id":"12915","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"12915"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00012915","sets":["147:215"]},"author_link":["17952","17951","17953"],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-06-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"28","bibliographicPageStart":"19","bibliographicVolumeNumber":"58","bibliographic_titles":[{"bibliographic_title":"岐阜薬科大学紀要"},{"bibliographic_title":"The annual proceedings of Gifu Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中野, 浩士"}],"nameIdentifiers":[{"nameIdentifier":"17951","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ナカノ, コウジ"}],"nameIdentifiers":[{"nameIdentifier":"17952","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"NAKANO, Koji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"17953","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"薬物の精密投与を達成するための有効な手段として、微粒子担体を用いたDDS（ドラッグデリバリーシステム）製剤に対する期待が高まっている。薬物送達を目指した微粒子製剤を設計する場合、微粒子担体の粒子径、表面電荷及び表面特性などの粒子物性は、その物理化学的及び生体内安定性はもとより、その薬物送達機能を向上させる上で重要な因子である。微粒子担体としてリポソームは特に、これらの物性を制御しやすい担体として注目されている。従来、リポソームのようなサブミクロン粒子の物性を評価する手法としては、粒子径やゼータ電位測定、走査型及び透過型顕微鏡を用いた形状観察による評価などに限定されており、高機能な微粒子製剤を開発するためには、新しい視点での物性評価が強く求められている。本研究では、サブミクロン粒子の新規物性評価法の確立を目的とし、原子間力顕微鏡を用いて、リポソームの硬さについて評価を行った。また粒子の表面物性が生体組織との相互作用に与える影響に関してin vitro及びin vivoにて評価し、リポソームの経肺投与型製剤としての可能性についても検討した。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"The Drug Delivery System (DDS) raises expectations as an effective method of achieving precise administration of active pharmaceutical ingredients. Concerning formulating fine-particle products for drug delivery, physicochemical properties of particles, such as particle size, surface charge or surface condition are important factors for increasing the function of drug delivery. Liposomes as drug carriers are quite useful for controlling these properties. Methods for evaluating physicochemical properties of submicron-sized particles are limited to the measurement of particle size or zeta potential and observation of morphology with a scanning or transmission electron microscope. Therefore, a novel evaluation method is needed to develop a functional product of fine particles. The rigidity of liposomes is evaluated with an atomic force microscope for the purpose of establishing a novel evaluation method. The effects of surface properties on bio-interaction are also evaluated in vitro or in vivo then the possibility of polymer-coated liposomes as the dosage form for pulmonary administration is investigated.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA1258935X","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University"}]},"item_1_text_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_text_value":"総説"}]},"item_1_text_3":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Review"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"岐阜薬科大学薬物送達学大講座製剤学研究室"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-07-01"}],"displaytype":"detail","filename":"リポソームの物理化学的性質の新規な評価法及び生体組織との相互作用制御に関する研究.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"リポソームの物理化学的性質の新規な評価法及び生体組織との相互作用制御に関する研究","url":"https://gifu-pu.repo.nii.ac.jp/record/12915/files/リポソームの物理化学的性質の新規な評価法及び生体組織との相互作用制御に関する研究.pdf"},"version_id":"6c94556c-d482-4418-9e89-0cb6ebc2d268"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"リポソーム","subitem_subject_scheme":"Other"},{"subitem_subject":"原子間力顕微鏡","subitem_subject_scheme":"Other"},{"subitem_subject":"ポリマー修飾","subitem_subject_scheme":"Other"},{"subitem_subject":"フローサイトメトリー","subitem_subject_scheme":"Other"},{"subitem_subject":"キトサン","subitem_subject_scheme":"Other"},{"subitem_subject":"経肺投与","subitem_subject_scheme":"Other"},{"subitem_subject":"liposomes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"atomic force microscopy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"polymer coating","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"flow cytometry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chitosan","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pulmonary administration","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"リポソームの物理化学的性質の新規な評価法及び生体組織との相互作用制御に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"リポソームの物理化学的性質の新規な評価法及び生体組織との相互作用制御に関する研究"},{"subitem_title":"Methods for Measuring Rigidity of Liposomes and Effect of Surface Modification of Submicron-sized Particles on Bio-interaction","subitem_title_language":"en"}]},"item_type_id":"1","owner":"4","path":["215"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-06-27"},"publish_date":"2014-06-27","publish_status":"0","recid":"12915","relation_version_is_last":true,"title":["リポソームの物理化学的性質の新規な評価法及び生体組織との相互作用制御に関する研究"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-06-19T09:03:00.546163+00:00"}