{"created":"2023-06-19T07:25:15.849763+00:00","id":12927,"links":{},"metadata":{"_buckets":{"deposit":"634ddf51-4375-48bd-8de4-f04585600fb4"},"_deposit":{"created_by":4,"id":"12927","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"12927"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00012927","sets":["147:216"]},"author_link":["17969","17970","17971","17968","17972","17967"],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-06-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"16","bibliographicPageStart":"8","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"岐阜薬科大学紀要　"},{"bibliographic_title":"The annual proceedings of Gifu Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"森, 重樹"}],"nameIdentifiers":[{"nameIdentifier":"17967","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐治木, 弘尚"}],"nameIdentifiers":[{"nameIdentifier":"17968","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"モリ, シゲキ"}],"nameIdentifiers":[{"nameIdentifier":"17969","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"サジキ, ヒロナオ"}],"nameIdentifiers":[{"nameIdentifier":"17970","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"MORI, Shigeki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"17971","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SAJIKI, Hironao","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"17972","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"アルキンからアルケンへの選択的部分水素化は生物活性分子、天然物、工業材料合成などに幅広く利用される\n重要な反応である。これまでにも盛んに研究されており、炭酸カルシウム（CaCO3）にPd を担持し鉛を触媒毒として用\nいたLindlar 触媒にキノリンを添加する反応が最も効率的な手法とされている。しかし毒性の高い鉛による前処理と、反\n応系へのキノリンの添加が必要であるうえ、一置換アルキンには適用が困難であるなどの欠点を有している。\n著者らの研究室では、触媒毒である窒素性塩基を利用した触媒の開発とともに官能基選択的接触還元法確立に成功し\nている。この検討過程で、分子内に多数の窒素性塩基を有するポリマーであるポリエチレンイミン(PEI)がPd を高度に被\n毒する担体として利用できると考えた。詳細な検討の結果、パラジウム－ポリエチレンイミン ［Pd(0)-PEI］ 触媒の一\n般性ある調製法を確立するとともに、二置換および一置換アルキンの高選択的部分水素化法を確立することができた。さ\nらに、他の還元性官能基存在下アルキンのみをアルケンに水素化する手法としても利用できることを明らかにした。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"The selective partial hydrogenation of alkynes to alkenes represents an important class of chemical transformations that\nhave found extensive use in the construction of enormous bioactive molecules, natural products, and industrial materials as well as\nmany others. The important transformation has typically been accomplished under ordinary hydrogen pressure and at room\ntemperature using heterogeneous Pd catalysts such as the Lindlar catalyst [Pd/CaCO3-Pb(OAc)2 in conjunction with quinoline]. The\nLindlar method, however, requires the pretreatment with harmful Pb(OAc)2 and the simultaneous use of quinoline. Furthermore, the\nsmooth over-reduction of mono-substituted (terminal) alkynes to the corresponding alkanes proceeded readily.\nWe have developed chemoselective hydrogenation methods and catalysts with the addition or immobilization of\nnitrogen-containing bases as a catalyst poison. During our effort to develop a Pd catalyst for hydrogenation by possessing different\nchemoselectivities, we found that polyethyleneimine (PEI, branched polymer) was likely to be a good carrier of highly poisoned Pd\nmetal. After detailed investigations, we developed a general preparation method for the Pd(0)-PEI catalyst and applied it to the partial\nhydrogenation of various alkynes to the corresponding alkenes. Moreover, we accomplished the highly chemoselective\nhydrogenation of alkynes to alkenes with the Pd(0)-PEI catalyst leaving the other reducible functionalities intact.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA1258935X","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Product Development Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc."},{"subitem_text_language":"en","subitem_text_value":"Laboratory of Organic Chemistry, Gifu Pharmaceutical University"}]},"item_1_text_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_text_value":"総説"}]},"item_1_text_3":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Review"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"日本たばこ産業株式会社 医薬総合研究所 生産技術研究所 第６グループ"},{"subitem_text_value":"岐阜薬科大学 創薬化学大講座 薬品化学研究室"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-07-28"}],"displaytype":"detail","filename":"パラジウム－ ポリエチレンイミン触媒の開発とアルキン部分水素化反応への応用.pdf","filesize":[{"value":"596.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"パラジウム－ ポリエチレンイミン触媒の開発とアルキン部分水素化反応への応用","url":"https://gifu-pu.repo.nii.ac.jp/record/12927/files/パラジウム－ ポリエチレンイミン触媒の開発とアルキン部分水素化反応への応用.pdf"},"version_id":"5299c44f-ba0f-4c33-b56d-3c8c9572ad9f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"パラジウム(Pd)","subitem_subject_scheme":"Other"},{"subitem_subject":"ポリエチレンイミン(PEI)","subitem_subject_scheme":"Other"},{"subitem_subject":"アルキン","subitem_subject_scheme":"Other"},{"subitem_subject":"部分水素化","subitem_subject_scheme":"Other"},{"subitem_subject":"palladium (Pd)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"polyethyleneimine (PEI)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"alkynes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"partial hydrogenation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"パラジウム－ ポリエチレンイミン触媒の開発とアルキン部分水素化反応への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"パラジウム－ ポリエチレンイミン触媒の開発とアルキン部分水素化反応への応用"},{"subitem_title":"Development of palladium-polyethyleneimine catalyst and its application to partial hydrogenation of alkynes to alkenes","subitem_title_language":"en"}]},"item_type_id":"1","owner":"4","path":["216"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-07-28"},"publish_date":"2014-07-28","publish_status":"0","recid":"12927","relation_version_is_last":true,"title":["パラジウム－ ポリエチレンイミン触媒の開発とアルキン部分水素化反応への応用"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-06-19T09:02:42.741026+00:00"}