{"created":"2023-06-19T07:25:17.276839+00:00","id":12962,"links":{},"metadata":{"_buckets":{"deposit":"69f70287-9477-4557-a24c-696cfb676151"},"_deposit":{"created_by":4,"id":"12962","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"12962"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00012962","sets":["147:219"]},"author_link":["18042","18044","18046","18047","18043","18045"],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-06-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"21","bibliographicPageStart":"12","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"岐阜薬科大学紀要"},{"bibliographic_title":"The annual proceedings of Gifu Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大八木, 篤"}],"nameIdentifiers":[{"nameIdentifier":"18042","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原, 英彰"}],"nameIdentifiers":[{"nameIdentifier":"18043","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"オオヤギ, アツシ"}],"nameIdentifiers":[{"nameIdentifier":"18044","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ハラ, ヒデアキ"}],"nameIdentifiers":[{"nameIdentifier":"18045","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"OYAGI, Atsushi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18046","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HARA, Hideaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18047","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"ヘパリン結合性上皮成長因子(heparin-binding epidermal growth factor-like growth factor: HB-EGF)はEGF ファミリー\nの主要な増殖因子の一つである。これまでの研究で、HB-EGF は生体内で細胞の癌化、正常な心臓機能の発現、表皮の創\n傷治癒、目蓋の形成などに関与していることが報告されている。一方、HB-EGF は海馬や大脳皮質、小脳など中枢神経系\nで高い発現を示すことから、神経細胞のネットワーク回路の構築や高次脳機能への関与が示唆される。そこで、前脳選択\n的にHB-EGF 欠損させたマウスを作製し、中枢神経系の高次脳機能におけるHB-EGF の役割について検討した。前脳選\n択的HB-EGF 欠損マウスは自発運動量の増加や社会性行動の低下、プレパルスインヒビションの低下、記憶の低下など\nの諸種の行動変化を示した。また、HB-EGF KO マウスではドパミンやセロトニンなどの脳内モノアミン含量の変化や、\n大脳皮質第三層のスパイン密度の低下、海馬における長期増強(LTP)の低下などの機能的・器質的変化を示した。以上よ\nりHB-EGF は、精神行動や記憶などの中枢神経系の高次脳機能の調節に重要な役割を果たしていることが示唆された。\nさらにHB-EGF シグナルの制御が複雑な神経疾患の病態機序解明、新規治療法並びに治療薬の開発の糸口になることが\n期待できる。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family of growth factors.\nPreviously, HB-EGF has been reported to be involved in diverse biological processes, including tumor formation, heart function,\nwound healing, and eyelid formation. On the other hand, HB-EGF is widely expressed in the central nervous system, including the\nhippocampus, cerebral cortex and cerebellum, and is considered to play pivotal roles in the development of the adult nervous system\nand higher brain function. We generated mice in which HB-EGF activity is disrupted specifically in the ventral forebrain and\ninvestigated the roles of HB-EGF in higher brain function. These knockout mice showed behavioral abnormalities such as an\nincrease in locomotor activity, decreased social interaction, a deficit of prepulse inhibition, and memory impairment. HB-EGF KO\nmice also showed altered monoamine factors such as dopamine and serotonin, decreased spine density in neurons of the prefrontal\ncortex, and impaired long-term potentiation (LTP) in the hippocampus. These results suggest that HB-EGF exerts significant\ninfluence in higher brain functions, such as psychomotor behavior and memory formation and careful regulation of its activity will be\nan important goal for treating a number of neurological diseases of the central nervous system.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA1258935X","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Molecular Pharmacology, Gifu Pharmaceutical University"}]},"item_1_text_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_text_value":"総説"}]},"item_1_text_3":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Review"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"岐阜薬科大学生体機能解析学大講座薬効解析学研究室"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-08-01"}],"displaytype":"detail","filename":"前脳選択的HB-EGF 欠損マウスを用いた、中枢神経系の高次脳機能におけるHB-EGF の役割.pdf","filesize":[{"value":"869.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"前脳選択的HB-EGF 欠損マウスを用いた、中枢神経系の高次脳機能におけるHB-EGF の役割","url":"https://gifu-pu.repo.nii.ac.jp/record/12962/files/前脳選択的HB-EGF 欠損マウスを用いた、中枢神経系の高次脳機能におけるHB-EGF の役割.pdf"},"version_id":"a94f8a42-3a6d-40ec-8689-6585ed52aab1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"高次脳機能","subitem_subject_scheme":"Other"},{"subitem_subject":"長期増強","subitem_subject_scheme":"Other"},{"subitem_subject":"ヘパリン結合性上皮成長因子","subitem_subject_scheme":"Other"},{"subitem_subject":"KO マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"HB-EGF","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"higher brain function","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"KO mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"LTP","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"前脳選択的HB-EGF 欠損マウスを用いた、中枢神経系の高次脳機能におけるHB-EGF の役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"前脳選択的HB-EGF 欠損マウスを用いた、中枢神経系の高次脳機能におけるHB-EGF の役割"},{"subitem_title":"Roles of Heparin-binding EGF-like Growth Factor (HB-EGF) in the Higher Brain Functions: Analysis of Ventral Forebrain Specific HB-EGF KO Mice","subitem_title_language":"en"}]},"item_type_id":"1","owner":"4","path":["219"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-08-01"},"publish_date":"2014-08-01","publish_status":"0","recid":"12962","relation_version_is_last":true,"title":["前脳選択的HB-EGF 欠損マウスを用いた、中枢神経系の高次脳機能におけるHB-EGF の役割"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-06-19T09:01:42.064288+00:00"}