{"created":"2023-06-19T07:25:17.359318+00:00","id":12964,"links":{},"metadata":{"_buckets":{"deposit":"752185ad-6867-492b-9245-348f8cf41d00"},"_deposit":{"created_by":4,"id":"12964","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"12964"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00012964","sets":["147:219"]},"author_link":["18061","18057","18065","18059","18062","18058","18064","18060","18063"],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-06-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"37","bibliographicPageStart":"32","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"岐阜薬科大学紀要　"},{"bibliographic_title":"The annual proceedings of Gifu Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高橋, 圭太"}],"nameIdentifiers":[{"nameIdentifier":"18057","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"杉山, 剛志"}],"nameIdentifiers":[{"nameIdentifier":"18058","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 裕志"}],"nameIdentifiers":[{"nameIdentifier":"18059","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"タカハシ, ケイタ"}],"nameIdentifiers":[{"nameIdentifier":"18060","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"スギヤマ, ツヨシ"}],"nameIdentifiers":[{"nameIdentifier":"18061","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"モリ, ヒロシ"}],"nameIdentifiers":[{"nameIdentifier":"18062","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"TAKAHASHI, Keita","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18063","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SUGIYAMA, Tsuyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18064","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MORI, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18065","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"蜂産品の一つであるローヤルゼリーは、ミツバチの働き蜂の分泌物である。女王蜂となる幼虫はローヤルゼリーの\nみを食べて成長する。ローヤルゼリーの脂質成分の大半を占める10-Hydroxy-trans-2-decenoic acid（10H2DA）は他の食品\nには含まれないローヤルゼリーに特有の脂肪酸である。10-Hydroxydecanoic acid（10HDA）は10H2DA に次いでローヤル\nゼリー中の含有量が高い脂肪酸である。これらの脂肪酸は様々な生理活性（抗腫瘍作用、エストロゲン様作用等）を示す\nことが報告されている。最近、我々は、10H2DA および10HDA が自然免疫受容体のシグナル伝達を抑制することを見出\nした。本総説では、10H2DA および10HDA の生理活性のうち、我々の研究で明らかになった免疫調節作用とその作用機\n序について記述する。加えて、これらの活性が免疫系の疾患に対する治療薬開発につながる可能性についても論じる。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Royal jelly is one of many bee products and a secretion of worker honeybees. Worker honeybees feed the queen honeybee\nfor her life with only royal jelly. 10-Hydroxy-trans-2-decenoic acid (10H2DA) is the principal lipid component in royal jelly.\n10-Hydroxydecanoic acid (10HDA) is also contained in royal jelly. These fatty acids have been reported to show several biological\nactivities, such as anti-tumor and estrogenic activity. Recently, we revealed the inhibitory effect of these fatty acids on innate immune\nreceptor signals. In this review, we focus on the biological activities of 10H2DA and 10HDA (especially immunomodulatory\nactivities). We also discuss the mechanisms underlying these biological activities and the possibilities for using these fatty acids as\nlead compounds in new therapeutic drugs for immune disorders.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA1258935X","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Laboratory of Microbiology, Gifu Pharmaceutical University"}]},"item_1_text_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_text_value":"総説"}]},"item_1_text_3":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Review"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"岐阜薬科大学生命薬学大講座微生物学研究室"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-08-01"}],"displaytype":"detail","filename":"自然免疫受容体シグナルに対するローヤルゼリー由来脂肪酸の抑制作用.pdf","filesize":[{"value":"548.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"自然免疫受容体シグナルに対するローヤルゼリー由来脂肪酸の抑制作用","url":"https://gifu-pu.repo.nii.ac.jp/record/12964/files/自然免疫受容体シグナルに対するローヤルゼリー由来脂肪酸の抑制作用.pdf"},"version_id":"e05ce27d-ffc6-40f4-a7bd-5cfec20c9157"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"自然免疫","subitem_subject_scheme":"Other"},{"subitem_subject":"ローヤルゼリー","subitem_subject_scheme":"Other"},{"subitem_subject":"toll-like receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"lipopolysaccharide","subitem_subject_scheme":"Other"},{"subitem_subject":"IFN","subitem_subject_scheme":"Other"},{"subitem_subject":"脂肪酸","subitem_subject_scheme":"Other"},{"subitem_subject":"innate immunity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"royal jelly","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"toll-like receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lipopolysaccharide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IFN","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fatty acids","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"自然免疫受容体シグナルに対するローヤルゼリー由来脂肪酸の抑制作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"自然免疫受容体シグナルに対するローヤルゼリー由来脂肪酸の抑制作用"},{"subitem_title":"Inhibitory Effects of Royal Jelly-derived Fatty Acids on Cellular Signal Transduction in Innate Immune Responses","subitem_title_language":"en"}]},"item_type_id":"1","owner":"4","path":["219"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-08-01"},"publish_date":"2014-08-01","publish_status":"0","recid":"12964","relation_version_is_last":true,"title":["自然免疫受容体シグナルに対するローヤルゼリー由来脂肪酸の抑制作用"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-06-19T09:01:38.098511+00:00"}