{"created":"2023-06-19T07:25:17.400871+00:00","id":12965,"links":{},"metadata":{"_buckets":{"deposit":"40b33cc8-ae07-46c3-9bf0-f099aa55ac52"},"_deposit":{"created_by":4,"id":"12965","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"12965"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00012965","sets":["147:219"]},"author_link":["18066","18069","18073","18068","18074","18070","18067","18072","18071"],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-06-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"47","bibliographicPageStart":"38","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"岐阜薬科大学紀要　"},{"bibliographic_title":"The annual proceedings of Gifu Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中島, 健一"}],"nameIdentifiers":[{"nameIdentifier":"18066","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大山, 雅義"}],"nameIdentifiers":[{"nameIdentifier":"18067","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"飯沼, 宗和"}],"nameIdentifiers":[{"nameIdentifier":"18068","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ナカシマ, ケンイチ"}],"nameIdentifiers":[{"nameIdentifier":"18069","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"オオヤマ, マサヨシ"}],"nameIdentifiers":[{"nameIdentifier":"18070","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"イイヌマ, ムネカズ"}],"nameIdentifiers":[{"nameIdentifier":"18071","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"NAKASHIMA, Ken-ichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18072","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"OYAMA, Masayoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18073","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"IINUMA, Munekazu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18074","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"アワダン属（Melicope）植物は、東南アジア、オセアニア等に約230 種が分布しているミカン科植物（Rutaceae）\nである。本属植物の一部は皮膚疾患や創傷の治療などの目的で伝承薬として用いられており、過去の研究において、多様\nで特異的な二次代謝産物が多数報告されている点から成分研究の対象として着目した。そこで我々は、国内外の2 種のア\nワダン属植物について成分精査を行った。その結果、沖縄県に生育するアワダン（M. triphylla）の果実から、8-geranyloxy-\n5-methoxypsoralen の酸化代謝産物であり、水酸基あるいはヒドロペルオキシ基を有する4 種の新規フラノクマリン誘導体\nmelicotriphyllin A–D を単離した。また、インドネシア等に生育するM. denhamii の葉部からは、新規化合物として、8 種\nのキノリノンアルカロイドmelicodenine A – H、2 種のフェニルプロパノイドmelicodin A およびB、クマリノリグノイド\nmelicodin C を、地下部からは5 種のグアイアン型あるいはジエラン型の骨格を有するセスキテルペノイドmelicodenone A\n– E を単離した。Melicodenine A – H およびmelicodin C は、Diels–Alder 環化付加反応または［2 + 2］環化付加反応により\n２分子が重合した過去に報告例のない骨格を有していた。さらに、その構成単位となる分子として、キノリノンアルカロ\nイドであるN-methylflindersine を中心に、アセトフェノン、フェニルプロパノイド、フラノクマリンのように多岐に及ぶ\n成分が重合に関与しており、非常に稀有な成分であるといえる。また、melicodenone A およびB は、天然から２例目およ\nび３例目となるジエラン型セスキテルペノイドであった。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Melicope (Rutaceae) consists of approximately 230 species and ranges from the Malagacy region east to the Pacific basin\nand south to New Zealand. A huge variety of secondary metabolites were isolated from the plants of Melicope genus, acetophenones,\nquinolinone- and furoquinoline-alkaloids, coumarins, and polymethoxyflavonoids. In the current study, two species of M. triphylla\n(LAM.) MERR. and M. denhamii (SEEM.) T. G. HARTLEY were investigated to obtain four new furanocoumarins melicotriphyllins A–D,\neight novel alkaloids melicodenines A–H, three new phenylpropanoids melicodins A–C, and five new sesquiterpenes melicodenones\nA–E. These structures were established by spectroscopic analyses, including extensive 1D and 2D NMR experiments.\nMelicotriphyllins A–D were linear-types of furanocoumarins bearing a hydroxyl or a hydroperoxy group on the geranyloxy side\nchain. Melicodenine A was a bisquinolinone alkaloid comprised of two N-methylflindersine, while melicodenines B–H were\ncomposed of single molecular N-methylflindersine with acetophenones or furanocoumarin or phenylpropanoids. These novel\nquinolinone alkaloids were presumed to form through the Diels-Alder or [2+2] cycloaddition. Furthermore, melicodenones A and B\nwere the first bicyclic zierane-type sesquiterpenes obtained from plant resources by the isolation of zierane.\n","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA1258935X","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Laboratory of Medicinal Resources, School of Pharmacy, Aichi Gakuin University"},{"subitem_text_language":"en","subitem_text_value":"Laboratory of Pharmacognosy, Gifu Pharmaceutical University"}]},"item_1_text_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_text_value":"総説"}]},"item_1_text_3":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Review"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"愛知学院大学薬学部薬用資源学講座"},{"subitem_text_value":"岐阜薬科大学機能分子学大講座生薬学研究室"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-08-01"}],"displaytype":"detail","filename":"ミカン科アワダン属植物の成分に関する研究.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"ミカン科アワダン属植物の成分に関する研究","url":"https://gifu-pu.repo.nii.ac.jp/record/12965/files/ミカン科アワダン属植物の成分に関する研究.pdf"},"version_id":"c8056bbb-a7d2-45dc-a8df-8573bb825e3a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Melicope triphylla","subitem_subject_scheme":"Other"},{"subitem_subject":"Melicope denhamii","subitem_subject_scheme":"Other"},{"subitem_subject":"フラノクマリン","subitem_subject_scheme":"Other"},{"subitem_subject":"ビスキノリノンアルカロイド","subitem_subject_scheme":"Other"},{"subitem_subject":"セスキテルペン","subitem_subject_scheme":"Other"},{"subitem_subject":"Melicope triphylla","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Melicope denhamii","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"furanocoumarin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"bisquinolinone alkaloid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"sesquiterpene","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ミカン科アワダン属植物の成分に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ミカン科アワダン属植物の成分に関する研究"},{"subitem_title":"Chemical Constituents of Melicope Species (Rutaceae)","subitem_title_language":"en"}]},"item_type_id":"1","owner":"4","path":["219"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-08-01"},"publish_date":"2014-08-01","publish_status":"0","recid":"12965","relation_version_is_last":true,"title":["ミカン科アワダン属植物の成分に関する研究"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-06-19T09:01:35.588403+00:00"}