{"created":"2023-06-19T07:25:19.867949+00:00","id":13032,"links":{},"metadata":{"_buckets":{"deposit":"da7938bf-788d-427b-b30e-e87f13302b06"},"_deposit":{"created_by":4,"id":"13032","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"13032"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00013032","sets":["147:228"]},"author_link":["18209","18206","18208","18211","18207","18210"],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"19","bibliographicPageStart":"11","bibliographicVolumeNumber":"65","bibliographic_titles":[{"bibliographic_title":"岐阜薬科大学紀要　"},{"bibliographic_title":"The annual proceedings of Gifu Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石坂, 光絵"}],"nameIdentifiers":[{"nameIdentifier":"18206","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原, 英彰"}],"nameIdentifiers":[{"nameIdentifier":"18207","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"イシサカ, ミツエ"}],"nameIdentifiers":[{"nameIdentifier":"18208","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ハラ, ヒデアキ"}],"nameIdentifiers":[{"nameIdentifier":"18209","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ISHISAKA, Mitsue","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18210","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HARA, Hideaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18211","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"ジアシルグリセロールキナーゼ (DGK) はジアシルグリセロールをリン酸化し、ホスファチジン酸へと変換する酵\n素である。現在までに哺乳類において10 種類のアイソフォームが同定されており、脳において強く発現していることが\n知られている。DGKβ はI 型に分類されるDGK アイソフォームであり、マウス脳においては、嗅球、皮質、海馬、線条\n体において特に強く発現している。しかしながら、その機能については不明な点が多いため、DGKβ 欠損マウスを用いて\n表現型解析を行った。DGKβ 欠損マウスでは、躁病様の表現型が認められ、これら表現型は既存の躁病治療薬で改善され\nることが明らかとなった。また、DGKβ 欠損マウスは多動性に加えて注意欠損様の行動が認められ、注意欠陥多動性障害\n(ADHD) 治療薬メチルフェニデートは注意欠損様の行動を改善することが示唆された。さらに、DGKβ 欠損マウスに痙攣\n誘発薬を投与したところ、痙攣行動の増悪が認められ、その一因に海馬における抑制性神経細胞の減少が考えられる。以\n上の結果より、DGKβ の欠損が躁病をはじめとする様々な疾患に関与している可能性およびこれら疾患の病態解明・治療\n薬探索にDGKβ 欠損マウスが有用であると考えられる。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Diacylglycerol kinase (DGK) is an enzyme that converts diacylglycerol to phosphatidic acid. To date, ten isoforms of\nDGKs have been identified in mammals, and it is reported that DGKs is strongly expressed in the brain. DGKβ, a type of DGK, is\nexpressed in the olfactory bulb, cortex, hippocampus, and striatum. The roles of DGKβ are still unknown. We generated the DGKβ\nknockout (KO) mice and investigated the phenotypes of DGKβ KO mice. DGKβ KO mice showed mania-like behaviors such as\nhyperactivity and reduced anxiety. These mania-like behaviors were ameliorated after commonly used medication for mania were\nadministered. Furthermore, DGKβ KO mice showed attention-deficit behavior, which was ameliorated by treatment with\nmethylphenidate. Furthermore, DGKβ KO mice showed increased seizure sensitivity due to the decreased numbers of depressor\nneurons in the hippocampus. These results suggest that deficit of DGKβ is involved in various neurological diseases including mania,\nand DGKβ KO mice would be useful to elucidate the pathogenesis and find the therapeutic targets in these disorders of the central\nnervous system.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA1258935X","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Molecular Pharmacology, Department of Biofunctional Evaluation,Gifu Pharmaceutical University"}]},"item_1_text_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_text_value":"総説"}]},"item_1_text_3":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Review"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"岐阜薬科大学生体機能解析学大講座薬効解析学研究室"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-07-29"}],"displaytype":"detail","filename":"no65 12-20.pdf","filesize":[{"value":"805.0 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"no65 12-20","url":"https://gifu-pu.repo.nii.ac.jp/record/13032/files/no65 12-20.pdf"},"version_id":"08789bfc-4ee9-4e9a-9ff6-fc72dc2d0e39"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ジアシルグリセロールキナーゼβ","subitem_subject_scheme":"Other"},{"subitem_subject":"高次脳機能","subitem_subject_scheme":"Other"},{"subitem_subject":"欠損マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"diacylglycerol kinase β","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"higher brain function","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"knock-out mice","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ジアシルグリセロールキナーゼβ (DGKβ) 欠損マウスを用いた高次脳機能におけるDGKβ の機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ジアシルグリセロールキナーゼβ (DGKβ) 欠損マウスを用いた高次脳機能におけるDGKβ の機能解析"},{"subitem_title":"The Role of Diacylglycerol Kinase β (DGKβ) in Higher Brain Function: Behavioral Analyses of DGKβ Knockout Mice","subitem_title_language":"en"}]},"item_type_id":"1","owner":"4","path":["228"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-07-29"},"publish_date":"2016-07-29","publish_status":"0","recid":"13032","relation_version_is_last":true,"title":["ジアシルグリセロールキナーゼβ (DGKβ) 欠損マウスを用いた高次脳機能におけるDGKβ の機能解析"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-06-19T08:59:38.738384+00:00"}