{"created":"2023-06-19T07:25:19.909862+00:00","id":13033,"links":{},"metadata":{"_buckets":{"deposit":"7da0d823-545b-4361-b6d8-87b4c0594dfa"},"_deposit":{"created_by":4,"id":"13033","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"13033"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00013033","sets":["147:228"]},"author_link":["18216","18215","18212","18214","18213","18217"],"item_1_biblio_info_14":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"27","bibliographicPageStart":"20","bibliographicVolumeNumber":"65","bibliographic_titles":[{"bibliographic_title":"岐阜薬科大学紀要　"},{"bibliographic_title":"The annual proceedings of Gifu Pharmaceutical University","bibliographic_titleLang":"en"}]}]},"item_1_creator_6":{"attribute_name":"著者名(日)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小川, 健二郎"}],"nameIdentifiers":[{"nameIdentifier":"18212","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原, 英彰"}],"nameIdentifiers":[{"nameIdentifier":"18213","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_7":{"attribute_name":"著者名よみ","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"オガワ, ケンジロウ"}],"nameIdentifiers":[{"nameIdentifier":"18214","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ハラ, ヒデアキ"}],"nameIdentifiers":[{"nameIdentifier":"18215","nameIdentifierScheme":"WEKO"}]}]},"item_1_creator_8":{"attribute_name":"著者名(英)","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"OGAWA, Kenjiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18216","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HARA, Hideaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"18217","nameIdentifierScheme":"WEKO"}]}]},"item_1_description_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_description":"P(論文)","subitem_description_type":"Other"}]},"item_1_description_11":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"わたし達の目は、日常的に太陽の紫外線や酸素などの影響を受けている。加えて、スマートフォンやパソコンな\nど電子端末機器の普及が進む現代社会において、目に関するトラブルの増加が懸念される。視機能の維持は我々のQOL\nに大きく関わるため、薬剤による治療や進行の抑制とともに、食品の機能性による予防も重要である。健康食品素材とし\nて広く利用されるビルベリーは、ブルーベリーの近縁種にあたる果実であり、果皮および果実内部にポリフェノールの一\n種であるアントシアニン色素を多く含んでいる。ビルベリー由来アントシアニンが目に与える機能性としては、in vitro\nおよびin vivo 試験において、網膜神経節細胞保護作用や光刺激に対する網膜視細胞保護作用、血管新生抑制作用、網膜\n炎症の軽減による視機能低下抑制作用などが報告されている。一方で、ヒト臨床試験の報告が少ないことが課題とされて\nいたが、2015 年4 月より新たな食品表示基準として機能性表示食品制度が施行されたことにより、ヒト臨床試験の報告\nが増えてきている。ビルベリーエキスに含まれるアントシアニン（以下、ビルベリー由来アントシアニン）においても新\nたな報告がなされている。ビルベリー由来アントシアニンを健常人が接種することで得られる機能性として、物の遠近を\n見る近見視力や毛様体筋の緊張状態、眼精疲労の客観的指標であるフリッカー値、および目の疲労感の主観的指標である\nvisual analogue scale（VAS）スコアや自覚症状アンケートにおいて、プラセボ接種群と比較して有意な改善が示されてい\nる。そのため、機能性表示食品として、目のピント調節力を改善すること、目の疲労感を和らげることが表示されている。\n今後もさらにヒト臨床試験が実施されることで、新たな機能性が明らかになることが予想される。","subitem_description_type":"Other"}]},"item_1_description_12":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Eyes are organs, which protrude outside the body, exposed to ultraviolet rays from the sun and oxygen. Furthermore, the\ndisorders of the eyes have increased due to the widespread use of electronic terminal equipment, such as smartphones and personal\ncomputers. Visual function is very important for our quality of life. Prevention of diseases by using drugs and beneficial food-derived\nsubstances is important. Bilberry, which is a species related to blueberry, contains large amounts of anthocyanin in the peel and fruit.\nThe beneficial effects of anthocyanins derived from bilberry on eye health, such as their protective effects on retinal ganglion cells\nagainst oxidative stress and on photoreceptor cells against light-induced damage, inhibitory effect against angiogenesis, and\ninhibitory effect on visual function decline by reducing inflammation in the retina, have been reported from in vitro and in vivo\nstudies. However, few human clinical trials on the intake of anthocyanins derived from bilberry are present. In Japan, the new system\nof functional display of foods started from April 2015, thereby resulting in some new results from human clinical trials with a\nsupplement containing anthocyanins derived from bilberry. The beneficial effects of anthocyanins derived from bilberry in humans\nhave been reported including improvement of factors such as near visual acuity, tension of the ciliary body, flicker fusion frequency\nindicative of eye strain, and visual analogue scale (VAS) score or subjective symptoms evaluation using questionnaires compared to\nplacebo. The beneficial effects of anthocyanins derived from bilberry have also been indicated in the improvement of eye focusing\nand reduction of eye fatigue. In the future, new beneficial functions related to eye health may emerge by conducting further human\nclinical trials with bilberry.","subitem_description_type":"Other"}]},"item_1_source_id_13":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA1258935X","subitem_source_identifier_type":"NCID"}]},"item_1_text_10":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Laboratory of Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University"}]},"item_1_text_2":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_text_value":"総説"}]},"item_1_text_3":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Review"}]},"item_1_text_9":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"岐阜薬科大学薬効解析学研究室"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-07-29"}],"displaytype":"detail","filename":"no65 21-28.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"no65 21-28","url":"https://gifu-pu.repo.nii.ac.jp/record/13033/files/no65 21-28.pdf"},"version_id":"b0683016-c6ee-4ee2-a494-6f59be9e28ac"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ビルベリー","subitem_subject_scheme":"Other"},{"subitem_subject":"アントシアニン","subitem_subject_scheme":"Other"},{"subitem_subject":"網膜","subitem_subject_scheme":"Other"},{"subitem_subject":"機能性","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト臨床試験","subitem_subject_scheme":"Other"},{"subitem_subject":"Bilberry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Anthocyanin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Retina","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"beneficial effects","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"human clinical trials","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ビルベリー由来アントシアニンが目に与える機能性 ―ヒト臨床試験と機能性表示食品―","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ビルベリー由来アントシアニンが目に与える機能性 ―ヒト臨床試験と機能性表示食品―"},{"subitem_title":"The beneficial effects of anthocyanins derived from bilberry on the eye","subitem_title_language":"en"}]},"item_type_id":"1","owner":"4","path":["228"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-07-29"},"publish_date":"2016-07-29","publish_status":"0","recid":"13033","relation_version_is_last":true,"title":["ビルベリー由来アントシアニンが目に与える機能性 ―ヒト臨床試験と機能性表示食品―"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-06-19T08:59:31.015854+00:00"}