{"created":"2023-06-19T07:25:21.379274+00:00","id":13111,"links":{},"metadata":{"_buckets":{"deposit":"a72527d4-f948-4e93-830e-31c87f3f9758"},"_deposit":{"created_by":24,"id":"13111","owners":[24],"pid":{"revision_id":0,"type":"depid","value":"13111"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00013111","sets":["212:253:333"]},"author_link":["18423","18425","18424","18421","18420","18422"],"item_3_biblio_info_3":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"41","bibliographicPageStart":"30","bibliographicVolumeNumber":"43","bibliographic_titles":[{},{"bibliographic_title":"Drug development and industrial pharmacy","bibliographic_titleLang":"en"}]}]},"item_3_text_4":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_text_value":"10.1080/03639045.2016.1201099"}]},"item_3_textarea_2":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_textarea_value":"Context: Dry powder inhaler (DPI) formulations have been developed to deliver large amounts of drugs to the lungs.\nObjective: Fine particles of a poorly water-soluble drug, the model drug ONO-2921, were prepared by the emulsion solvent diffusion (ESD) method for use in a DPI.\nMethods: The effects of additives on the fine particle formation of ONO-2921 were estimated when droplets of an ethanolic drug solution were dispersed into aqueous media containing various additives. Subsequently, the suspensions were freeze-dried to create powdered samples to estimate the inhalation properties using a twin impinger and an Andersen cascade impactor.\nResults: This simple ESD method produced submicron-sized ONO-2921 particles (approximately 600 nm) in combination with suitable additives. In addition, the freeze-dried powder produced using additives exhibited superior in vitro inhalation properties. Among these methods, the freeze-dried powder produced with 0.50% weight/volume one type of polyvinyl alcohol (PVA-205) displayed the most efficient features in the fine particle fraction (FPF). These results could be explained by the stabilization of the ONO-2921 suspension by PVA-205, indicating that PVA-205 acts as an aggregation inhibitor of fine particles. Conclusions: The ESD method, in combination with appropriate types and amounts of additives, may be useful for preparing a DPI suitable for delivering drugs directly to the lungs without the assistance of carrier particles."}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Administration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Inhalation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Chemistry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Pharmaceutical","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Diffusion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug Carriers","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dry Powder Inhalers","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Emulsions","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Particle Size","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"X-Ray Diffraction","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Appropriate selection of an aggregation inhibitor of fine particles used for inhalation prepared by emulsion solvent diffusion.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Appropriate selection of an aggregation inhibitor of fine particles used for inhalation prepared by emulsion solvent diffusion.","subitem_title_language":"en"}]},"item_type_id":"3","owner":"24","path":["333"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-07-12"},"publish_date":"2017-07-12","publish_status":"0","recid":"13111","relation_version_is_last":true,"title":["Appropriate selection of an aggregation inhibitor of fine particles used for inhalation prepared by emulsion solvent diffusion."],"weko_creator_id":"24","weko_shared_id":-1},"updated":"2023-06-19T08:58:22.230666+00:00"}