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Advanced Continuous Flow Platform for On‐Demand Pharmaceutical Manufacturing
https://gifu-pu.repo.nii.ac.jp/records/13114
https://gifu-pu.repo.nii.ac.jp/records/1311420b03d21-76c8-4de1-b0b7-bbdcb02a743a
| Item type | 研究室原著論文(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-01-31 | |||||
| タイトル | ||||||
| タイトル | Advanced Continuous Flow Platform for On‐Demand Pharmaceutical Manufacturing | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | active pharmaceutical ingredients | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | continuous flow chemistry | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | industrial chemistry | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | synthetic methods | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 抄録 | ||||||
| 値 | As a demonstration of an alternative to the challenges faced with batch pharmaceutical manufacturing including the large production footprint and lengthy time‐scale, we previously reported a refrigerator‐sized continuous flow system for the on‐demand production of essential medicines. Building on this technology, herein we report a second‐generation, reconfigurable and 25 % smaller (by volume) continuous flow pharmaceutical manufacturing platform featuring advances in reaction and purification equipment. Consisting of two compact [0.7 (L)×0.5 (D)×1.3 m (H)] stand‐alone units for synthesis and purification/formulation processes, the capabilities of this automated system are demonstrated with the synthesis of nicardipine hydrochloride and the production of concentrated liquid doses of ciprofloxacin hydrochloride, neostigmine methylsulfate and rufinamide that meet US Pharmacopeia standards. | |||||
| 書誌情報 |
Chemistry A European Journal 巻 24, 号 11, p. 2776-2784, 発行日 2018-02-21 |
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| DOI | ||||||
| 値 | 10.1002/chem.201706004 | |||||
