Advanced Continuous Flow Platform for On‐Demand Pharmaceutical Manufacturing

インデックスリンク

インデックスツリー

RootNode

アイテム

Advanced Continuous Flow Platform for On‐Demand Pharmaceutical Manufacturing

https://gifu-pu.repo.nii.ac.jp/records/13114

Item type		研究室原著論文(1)
公開日		2018-01-31
タイトル
	タイトル	Advanced Continuous Flow Platform for On‐Demand Pharmaceutical Manufacturing
言語
	言語	eng
キーワード
	主題Scheme	Other
	主題	active pharmaceutical ingredients
キーワード
	主題Scheme	Other
	主題	continuous flow chemistry
キーワード
	主題Scheme	Other
	主題	industrial chemistry
キーワード
	主題Scheme	Other
	主題	synthetic methods
資源タイプ
	資源タイプ識別子	http://purl.org/coar/resource_type/c_6501
	資源タイプ	journal article
アクセス権
	アクセス権	metadata only access
	アクセス権URI	http://purl.org/coar/access_right/c_14cb
抄録
	値	As a demonstration of an alternative to the challenges faced with batch pharmaceutical manufacturing including the large production footprint and lengthy time‐scale, we previously reported a refrigerator‐sized continuous flow system for the on‐demand production of essential medicines. Building on this technology, herein we report a second‐generation, reconfigurable and 25 % smaller (by volume) continuous flow pharmaceutical manufacturing platform featuring advances in reaction and purification equipment. Consisting of two compact [0.7 (L)×0.5 (D)×1.3 m (H)] stand‐alone units for synthesis and purification/formulation processes, the capabilities of this automated system are demonstrated with the synthesis of nicardipine hydrochloride and the production of concentrated liquid doses of ciprofloxacin hydrochloride, neostigmine methylsulfate and rufinamide that meet US Pharmacopeia standards.
書誌情報		Chemistry A European Journal 巻 24, 号 11, p. 2776-2784, 発行日 2018-02-21
DOI
	値	10.1002/chem.201706004