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Formulation design of granules prepared by wet granulation method using a multi-functional single-punch tablet press to avoid tableting failures
https://gifu-pu.repo.nii.ac.jp/records/13117
https://gifu-pu.repo.nii.ac.jp/records/13117ebc02699-b943-48b8-abac-1320e02088e2
| Item type | 研究室原著論文(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-08-10 | |||||
| タイトル | ||||||
| タイトル | Formulation design of granules prepared by wet granulation method using a multi-functional single-punch tablet press to avoid tableting failures | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | tableting | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | formulation design | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | wet granulation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | capping | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | binding | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | single-punch tablet press | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 抄録 | ||||||
| 値 | We previously determined “Tableting properties” by using a multi-functional single-punch tablet press (GTP-1). We plotted “Compactability” on the x-axis against “Manufacturability” on the y-axis to allow visual evaluation of “Tableting properties”. Here, we examined whether this evaluation method can be used in the formulation design of tablets prepared by wet granulation. We used the GTP-1 to measure “Tableting properties” with different amounts of binder, disintegrant, and lubricant, and compared the results with those of tableting on a commercial rotary tableting machine. Tableting failures (capping and binding in particular) occurred when samples that had been evaluated as having poor “Compactability” or “Manufacturability” on the GTP-1 were compressed on the rotary tableting machine. Thus, our evaluation method predicted tableting failure at the commercial scale. The method will prove useful for scaling up production. | |||||
| 書誌情報 |
Asian Journal of Pharmaceutical Sciences 巻 13, 号 2, p. 113-119, 発行日 2018-03 |
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| DOI | ||||||
| 値 | 10.1016/j.ajps.2017.08.002 | |||||
