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Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press
https://gifu-pu.repo.nii.ac.jp/records/13118
https://gifu-pu.repo.nii.ac.jp/records/13118c6036cc9-ee0a-4658-a31c-ede359c55083
| Item type | 研究室原著論文(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-03-17 | |||||
| タイトル | ||||||
| タイトル | Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch tablet press | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Tableting | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Formulation design | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Lubricant | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Punch shape | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Single-punch tablet press | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Losartan potassium | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 抄録 | ||||||
| 値 | We previously determined “Tableting properties” by using a multi-functional single-punch tablet press (GTP-1). We proposed plotting “Compactability” on the x-axis against “Manufacturability” on the y-axis to allow visual evaluation of “Tableting properties”. Various types of tableting failure occur in commercial drug production and are influenced by the amount of lubricant used and the shape of the punch. We used the GTP-1 to measure “Tableting properties” with different amounts of lubricant and compared the results with those of tableting on a commercial rotary tableting machine. Tablets compressed with a small amount of lubricant showed bad “Manufacturability”, leading to sticking of powder on punches. We also tested various punch shapes. The GTP-1 correctly predicted the actual tableting results for all punch shapes. With punches that were more likely to cause tableting failure, our system predicted the effects of lubricant quantity in the tablet formulation and the occurrence of sticking in the rotary tableting machine. | |||||
| 書誌情報 |
Asian Journal of Pharmaceutical Sciences 巻 12, 号 5, p. 412-417, 発行日 2017-11 |
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| DOI | ||||||
| 値 | 10.1016/j.ajps.2017.05.001 | |||||
