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Potential Interference of Oil Vehicles on Genital Tubercle Development during the Fetal Period in ICR Mice.
https://gifu-pu.repo.nii.ac.jp/records/13122
https://gifu-pu.repo.nii.ac.jp/records/131224cb0e2d8-5b8d-47ec-ad23-268401e6a7de
| Item type | 研究室原著論文(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-06-13 | |||||
| タイトル | ||||||
| タイトル | Potential Interference of Oil Vehicles on Genital Tubercle Development during the Fetal Period in ICR Mice. | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 抄録 | ||||||
| 値 | Corn oil, sesame oil, and 10% ethanol in corn oil are commonly used as dosing vehicles in toxicology studies. Since these vegetable oils contain bioactive compounds, it is important for toxicology studies to characterize the toxicities of the dosing vehicles themselves. It has been recently proposed that the width of the genital tubercle (GT), the dorsal–ventral length (D–V length) of the GT, and urethral tube closure in mouse fetuses can be used as novel markers for monitoring sexual development in mice. However, how these parameters are influenced by the dosing vehicles themselves remains unclear. Therefore, we evaluated the effects of corn oil, sesame oil, and 10% ethanol in corn oil on GT width, D–V length, and GT morphology in ICR mice. Our results showed that all three vehicles influenced GT width and D–V length, but not GT morphology, suggesting that the effects of dosing vehicles themselves might need to be considered when GT width or D–V length is used as a parameter to evaluate the effects of chemicals on GT development. | |||||
| 書誌情報 |
en : Biological & pharmaceutical bulletin 巻 41, 号 2, p. 266-271, 発行日 2018-06 |
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| DOI | ||||||
| 値 | 10.1248/bpb.b17-00830 | |||||
