Therapeutic Activities of DJ-1 and Its Binding Compounds Against Neurodegenerative Diseases.

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Therapeutic Activities of DJ-1 and Its Binding Compounds Against Neurodegenerative Diseases.

https://gifu-pu.repo.nii.ac.jp/records/13172

Item type		研究室原著論文(1)
公開日		2018-06-14
タイトル
	タイトル	Therapeutic Activities of DJ-1 and Its Binding Compounds Against Neurodegenerative Diseases.
言語
	言語	eng
資源タイプ
	資源タイプ識別子	http://purl.org/coar/resource_type/c_6501
	資源タイプ	journal article
アクセス権
	アクセス権	metadata only access
	アクセス権URI	http://purl.org/coar/access_right/c_14cb
抄録
	値	Parkinson's disease (PD) is a progressive neurodegenerative disorder that is primarily characterized by the degeneration of dopaminergic neurons in the nigrostriatal pathway. Loss-of-function mutations in the gene encoding PARK7/DJ-1 were identified in familial PD. Wild-type DJ-1 acts as an oxidative stress sensor in neural cells. Previously, we identified binding compounds of DJ-1, including UCP0045037/compound A, UCP0054278/compound B, and compound-23 (comp-23), by in silico virtual screening. These compounds prevented oxidative stress-induced dopaminergic neuronal death and restored locomotion defects in animal models of PD. In addition, these binding partners reduced infarct size in cerebral ischemia in rats. The neuroprotective effects of these compounds are lost in DJ-1-knockdown cells and DJ-1-knockout animal. These results suggest that these compounds interact with endogenous DJ-1 and then produce antioxidant and neuroprotective responses in both animal models for PD and cerebral ischemia in rats. This raises the possibility that interaction partners of DJ-1, such as UCP0045037, UCP0054278, and comp-23, may represent a novel dopaminergic neuroprotective drug for the treatment of PD.
書誌情報		Advances in Experimental Medicine and Biology 巻 1037, p. 187-202, 発行日 2017
DOI
	値	10.1007/978-981-10-6583-5_12