{"created":"2023-06-19T07:25:24.160043+00:00","id":13183,"links":{},"metadata":{"_buckets":{"deposit":"3923d2c4-d080-4ea4-b139-c4c531d3f8fc"},"_deposit":{"created_by":43,"id":"13183","owners":[43],"pid":{"revision_id":0,"type":"depid","value":"13183"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00013183","sets":["212:265:270"]},"author_link":["18893","18891","18892","18889","18890"],"item_3_biblio_info_3":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"68","bibliographicPageStart":"61","bibliographicVolumeNumber":"31","bibliographic_titles":[{},{"bibliographic_title":"Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine","bibliographic_titleLang":"en"}]}]},"item_3_text_4":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_text_value":"10.1007/s10534-017-0067-1"}]},"item_3_textarea_2":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_textarea_value":"Superoxide dismutase (SOD) 3, a copper (Cu)-containing anti-oxidative enzyme, plays a key role in extracellular redox homeostasis. Cu chaperone antioxidant-1 (Atox-1) not only delivers Cu ions to SOD3 at the trans-Golgi network, it also functions as a transcription factor of SOD3; however, the role of Atox-1 in the regulation of SOD3 during the monocytic differentiation of THP-1 cells has not yet been elucidated. A treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) induced the expression of the Cu transport protein ATP7A in THP-1 cells. On the other hand, the nuclear translocation of Atox-1 was detected in TPA-treated THP-1 cells, and was suppressed in the presence of the Cu chelator, bathocuproinedisulfonic acid. Furthermore, Atox-1 bound to the SOD3 promoter region in TPA-treated THP-1 cells. The overexpression of Atox-1 in THP-1 cells significantly enhanced TPA-elicited SOD3 expression, whereas its knockdown suppressed this induction. The present results demonstrate that Atox-1 functions as a key molecule in TPA-elicited SOD3 expression."}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Copper chaperone antioxidant-1, Atox-1, is involved in the induction of SOD3 in THP-1 cells.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Copper chaperone antioxidant-1, Atox-1, is involved in the induction of SOD3 in THP-1 cells."}]},"item_type_id":"3","owner":"43","path":["270"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-14"},"publish_date":"2018-06-14","publish_status":"0","recid":"13183","relation_version_is_last":true,"title":["Copper chaperone antioxidant-1, Atox-1, is involved in the induction of SOD3 in THP-1 cells."],"weko_creator_id":"43","weko_shared_id":-1},"updated":"2023-06-19T08:58:34.480319+00:00"}