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Chemical constituents of Aglaia odorata leaves and their anti-inflammatory effects
https://gifu-pu.repo.nii.ac.jp/records/13209
https://gifu-pu.repo.nii.ac.jp/records/13209cad36f91-9ca4-4d67-a56c-94ea5e85680c
| Item type | 研究室原著論文(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-06-14 | |||||
| タイトル | ||||||
| タイトル | Chemical constituents of Aglaia odorata leaves and their anti-inflammatory effects | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 抄録 | ||||||
| 値 | Aglaia odorata Lour. is a traditional herbal medicine belonging to the Meliaceae family. The aim of this study was to identify useful compounds for human health from A. odorata. Our phytochemical investigation resulted in the isolation of four constituents hesperetin-7,3′-O-dimethylether, 5α-dammar-20-ene- 3β,24,25-triol, odorine, and odorinol. All compounds suppressed LPS-induced TNF-α expression in rat immortalized microglia HAPI cells; especially, hesperetin-7,3′-O-dimethylether showed most potent inhibitory effect. In addition, molecular docking analysis demonstrated that hesperetin-7,3′-Odimethylether could be accommodated within hot spots of TNF-α dimeric protein. | |||||
| 書誌情報 |
en : Natural product communications 巻 12, 号 11, p. 1717-1720, 発行日 2017-09-08 |
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