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Preparation and Characterization of Polymeric Prodrugs of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) by Cold Plasma Technique
https://gifu-pu.repo.nii.ac.jp/records/13214
https://gifu-pu.repo.nii.ac.jp/records/13214617b6061-c8bf-4018-a79e-be415e0ed15a
| Item type | 研究室原著論文(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-05-12 | |||||
| タイトル | ||||||
| タイトル | Preparation and Characterization of Polymeric Prodrugs of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) by Cold Plasma Technique | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Plasma irradiation | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Drug delivery system | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Cellulose derivatives | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Polymeric prodrugs | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 抄録 | ||||||
| 値 | A methacrylic-type polymerizable derivative of naproxen (NP), planned as a prodrug, was directly synthesized from the reaction between 2-hydroxyethyl methacrylate (HEMA) and NP by the esterification method. Then, the polymeric prodrugs containing NP pendent groups were synthesized by the free radical polymerization on plasma irradiated pharmaceutical excipient powders. Hydrolysis of the polymeric prodrugs was carried out in conditions similar to physiological conditions and the results showed that the studied polymeric prodrugs in the present investigation can be used as carriers in controlled drug release, to meet the need for prolonged and better control of drug administration. | |||||
| 書誌情報 |
en : J. Photopolym. Sci. Technol. 巻 30, 号 3, p. 303-306, 発行日 2017 |
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| DOI | ||||||
| 値 | 10.2494/photopolymer.30.303 | |||||
