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腎機能低下患者へのtazobactam/piperacillinの投与が使用量サーベイランスに与える影響
https://gifu-pu.repo.nii.ac.jp/records/13245
https://gifu-pu.repo.nii.ac.jp/records/13245b1e609c1-0fbe-4c5c-9f74-1e658dccffe2
| Item type | 研究室原著論文(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-06-15 | |||||
| タイトル | ||||||
| タイトル | 腎機能低下患者へのtazobactam/piperacillinの投与が使用量サーベイランスに与える影響 | |||||
| タイトル | ||||||
| タイトル | Influence of dosages surveillance on the administration of tazobactam/piperacillin to patients with renal failure | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | tazobactam/piperacillin (TAZ/PIPC), renal function, surveillance, antimicrobial use density (AUD), days of therapy (DOT) | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 抄録 | ||||||
| 値 | The administration of tazobactam/piperacillin (TAZ/PIPC) to patients with renal failure requires dose reduction since it is eliminated through the kidneys. Therefore, we set TAZ/PIPC dose reduction criteria for the administration of TAZ/PIPC to renal failure patients, in addition, pharmacist checked renal function and dose for proper use. We investigated the influence of the rate of renal failure patients administered TAZ/PIPC on antimicrobial use density (AUD), days of therapy (DOT), and AUD/DOT. The rate of the number of patients administered TAZ/PIPC with renal failure, the rate of TAZ/PIPC dose and dosing days were calculated, and these variables were determined for each month of the study period. Furthermore, we assessed the correlations of AUD, DOT, AUD/DOT with patients rate, dose rate and dosing days rate for each month. As a result, AUD/DOT was significantly and negatively correlated with patients rete (r = -0.634, P = 0.027), dose rate (r = -0.783, P = 0.003), and dosing days rate (r = -0.695, P = 0.012). AUD/DOT is an indicator of the one-day dosing of antimicrobials. TAZ/PIPC one-day dose was accorded with renal function in 84.4% of cases owing to the dose reduction criteria and checked by the pharmacist in this study. This suggests that the dose of TAZ/PIPC was appropriately adjusted based on renal function. We found that as the rate of administration of TAZ/PIPC, eliminated through the kidneys, in patients with renal failure increased, AUD/DOT decreased. Our findings support the appropriate assessment of antimicrobial dosage surveillance. |
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| 書誌情報 |
医療薬学 巻 43, 号 11, p. 648-653, 発行日 2017-11 |
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