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A mitochondria-targeted fluorescent probe for selective detection of mitochondrial labile Fe(II)
https://gifu-pu.repo.nii.ac.jp/records/13273
https://gifu-pu.repo.nii.ac.jp/records/132732045a5f6-da1d-43fc-bb7e-17050fa61b86
| Item type | 研究室原著論文(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-05-21 | |||||
| タイトル | ||||||
| タイトル | A mitochondria-targeted fluorescent probe for selective detection of mitochondrial labile Fe(II) | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 抄録 | ||||||
| 値 | Mitochondria are iron-rich organelles that are involved in the process of energy production through the electron-transporting system and heme synthesis. We developed a new mitochondria-targeted fluorescent probe, MtFluNox/Ac-MtFluNox, for Fe(II) based on N-oxide chemistry, which we recently established as a Fe(II)-selective fluorogenic switch. The deacetylated form MtFluNox showed a turn-on response towards Fe(II) with high metal selectivity in cuvette experiments, and an imaging study using its cell-compatible analogue Ac-MtFluNox demonstrated mitochondria-specific fluorescence enhancement in response to Fe(II) in living cells. Furthermore, the probe was able to detect endogenously accumulated Fe(II) induced as a result of the inhibition of heme synthesis. | |||||
| 書誌情報 |
Metallomics 巻 10, p. 794-801, 発行日 2018-06-01 |
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| DOI | ||||||
| 値 | 10.1039/C8MT00049B | |||||
