{"created":"2023-06-19T07:25:27.477826+00:00","id":13273,"links":{},"metadata":{"_buckets":{"deposit":"65ffdde1-c9a9-4980-9787-c54e8e331ecf"},"_deposit":{"created_by":31,"id":"13273","owners":[31],"pid":{"revision_id":0,"type":"depid","value":"13273"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00013273","sets":["212:259:315"]},"author_link":["19600","19602","19601","19603"],"item_3_biblio_info_3":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-06-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"801","bibliographicPageStart":"794","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Metallomics"}]}]},"item_3_text_4":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_text_value":"10.1039/C8MT00049B"}]},"item_3_textarea_2":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_textarea_value":"Mitochondria are iron-rich organelles that are involved in the process of energy production through the electron-transporting system and heme synthesis. We developed a new mitochondria-targeted fluorescent probe, MtFluNox/Ac-MtFluNox, for Fe(II) based on N-oxide chemistry, which we recently established as a Fe(II)-selective fluorogenic switch. The deacetylated form MtFluNox showed a turn-on response towards Fe(II) with high metal selectivity in cuvette experiments, and an imaging study using its cell-compatible analogue Ac-MtFluNox demonstrated mitochondria-specific fluorescence enhancement in response to Fe(II) in living cells. Furthermore, the probe was able to detect endogenously accumulated Fe(II) induced as a result of the inhibition of heme synthesis."}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A mitochondria-targeted fluorescent probe for selective detection of mitochondrial labile Fe(II)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A mitochondria-targeted fluorescent probe for selective detection of mitochondrial labile Fe(II)"}]},"item_type_id":"3","owner":"31","path":["315"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-21"},"publish_date":"2018-05-21","publish_status":"0","recid":"13273","relation_version_is_last":true,"title":["A mitochondria-targeted fluorescent probe for selective detection of mitochondrial labile Fe(II)"],"weko_creator_id":"31","weko_shared_id":-1},"updated":"2023-06-19T08:57:25.253249+00:00"}