{"created":"2023-06-19T07:25:27.894472+00:00","id":13288,"links":{},"metadata":{"_buckets":{"deposit":"7d4eb4f7-5eeb-4bf1-84e3-22de6192012d"},"_deposit":{"created_by":47,"id":"13288","owners":[47],"pid":{"revision_id":0,"type":"depid","value":"13288"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00013288","sets":["212:262:306"]},"author_link":["19705","19710","19708","19703","19709","19702","19706","19707","19704"],"item_3_biblio_info_3":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"460","bibliographicPageStart":"454","bibliographicVolumeNumber":"42","bibliographic_titles":[{},{"bibliographic_title":"Journal of Clinical Pharmacy and Therapeutics","bibliographic_titleLang":"en"}]}]},"item_3_text_4":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_text_value":"10.1111/jcpt.12532"}]},"item_3_textarea_2":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_textarea_value":"WHAT IS KNOWN AND OBJECTIVE:\nA simple, rapid analysis is required to simultaneously analyse medicinal toxicants in emergency medical care. In this regard, the analysis of blood samples by LC-MS/MS equipped with a spin column, involving a rapid, simple pretreatment, has attracted attention. In this study, sample pretreatment using a Monospin C18 column was performed to screen 11 medicinal toxicants in blood samples by LC-MS/MS.\n\nMETHODS:\nSerum samples supplemented with 11 medical toxicants-acetaminophen, salicylic acid, nitrazepam, diphenhydramine, bromvalerylurea, phenobarbital, amitriptyline, risperidone, fenitrothion, malathion and methomyl-were pretreated with the Monospin C18 column according to Pretreatment I and Pretreatment II, followed by LC-MS/MS analysis.\n\nRESULTS AND DISCUSSION:\nAll toxicants were not detected by a single pretreatment method but were detected by two pretreatment methods. According to Pretreatment I, 10 medicinal toxicants-excluding salicylic acid-were detected. The recovery rates of all medicinal toxicants, except acetaminophen and methomyl, were greater than or equal to 80%. Salicylic acid was detected by Pretreatment II, with a recovery rate of 57.1%. Although the coefficient of variation was less than that reported in previous methods employing SPE, the recovery rates were better possibly because of the simultaneous adsorption of water- and lipid-soluble substances and evaporation by drying.\n\nWHAT IS NEW AND CONCLUSION:\nAs LC-MS/MS analysis using Monospin C18 can simultaneously and rapidly screen several medicinal toxicants present in blood samples, it is expected to be highly suitable for clinical settings."}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Chromatography, Liquid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hospitals","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Humans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Japan","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Pharmaceutical Preparations","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Poisoning","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tandem Mass Spectrometry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Time Factors","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A rapid method to screen poisoning causative agents in an acute care hospital in Japan.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A rapid method to screen poisoning causative agents in an acute care hospital in Japan.","subitem_title_language":"en"}]},"item_type_id":"3","owner":"47","path":["306"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-06"},"publish_date":"2018-07-06","publish_status":"0","recid":"13288","relation_version_is_last":true,"title":["A rapid method to screen poisoning causative agents in an acute care hospital in Japan."],"weko_creator_id":"47","weko_shared_id":-1},"updated":"2023-06-19T08:57:21.399840+00:00"}