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デンプン非含有Mohsペーストの調製と製剤評価
https://gifu-pu.repo.nii.ac.jp/records/13304
https://gifu-pu.repo.nii.ac.jp/records/133044c7bd173-cc47-47ca-8af9-0daa4401ba28
| Item type | 研究室原著論文(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-07-10 | |||||
| タイトル | ||||||
| タイトル | デンプン非含有Mohsペーストの調製と製剤評価 | |||||
| タイトル | ||||||
| タイトル | Preparation and Evaluation of Modified Mohs Paste without Starch | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 抄録 | ||||||
| 値 | Mohs paste is an external preparation containing zinc hydrochloride and zinc oxide starch as the main ingredient, and it is used for the palliative treatment of patients with surgically untreatable malignant tumors. However, it has problems, such as changes in hardness and viscoelasticity with time and liquefaction by exudate. To overcome these problems, we modified the formulation of Mohs paste by excluding starch, which is the cause of physical changes, and investigated the base. In the modified Mohs paste using the macrogol ointment for the base, no marked change with time was noted in the hardness, malleability, or elongation property, and the water-absorbing properties were equivalent to those of Mohs paste immediately after preparation. The hardness did not decrease even after absorbing water. The drug release rate increased 1.5 times with the modified Mohs paste. Based on these findings, the risk of liquefaction-associated damage of the surrounding skin decreased on using the modified Mohs paste, and preparing in advance became possible. These results suggest that the modified Mohs paste using the macrogol ointment for the base exhibits an equivalent effect for control of exudate and a high effect for tissue fixation. | |||||
| 書誌情報 |
薬学雑誌 en : YAKUGAKU ZASSHI 巻 137, 号 4, p. 477-484, 発行日 2017 |
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| DOI | ||||||
| 値 | 10.1248/yakushi.16-00248 | |||||
