{"created":"2023-06-19T07:25:41.203267+00:00","id":13707,"links":{},"metadata":{"_buckets":{"deposit":"f6d394bd-9a27-4e83-9584-1a25f3a2f3f7"},"_deposit":{"created_by":78,"id":"13707","owners":[78],"pid":{"revision_id":0,"type":"depid","value":"13707"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00013707","sets":["212:264:300"]},"author_link":["28971","28972","28970","28973","28969"],"item_3_biblio_info_3":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageStart":"2942","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"International Journal of Molecular Sciences"},{"bibliographic_title":"International Journal of Molecular Sciences","bibliographic_titleLang":"en"}]}]},"item_3_text_4":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_text_value":"10.3390/ijms20122942"}]},"item_3_textarea_2":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_textarea_value":"Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the selective death of motor neurons. In previous our study, an ethanol extract of Brazilian green propolis (EBGP) prevented mutant copper-zinc superoxide dismutase 1 (SOD1mut)-induced neurotoxicity. This paper aims to reveal the effects of p-coumaric acid (p-CA), an active ingredient contained in EBGP, against SOD1mut-induced neurotoxicity. We found that p-CA reduced the accumulation of SOD1mut subcellular aggregation and prevented SOD1mut-associated neurotoxicity. Moreover, p-CA attenuated SOD1mut-induced oxidative stress and endoplasmic reticulum stress, which are significant features in ALS pathology. To examine the mechanism of neuroprotective effects, we focused on autophagy, and we found that p-CA induced autophagy. Additionally, the neuroprotective effects of p-CA were inhibited by chloroquine, an autophagy inhibiter. Therefore, these results obtained in this paper suggest that p-CA prevents SOD1mut-induced neurotoxicity through the activation of autophagy and provides a potential therapeutic approach for ALS."}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"p-Coumaric Acid Has Protective Effects against Mutant Copper–Zinc Superoxide Dismutase 1 via the Activation of Autophagy in N2a Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"p-Coumaric Acid Has Protective Effects against Mutant Copper–Zinc Superoxide Dismutase 1 via the Activation of Autophagy in N2a Cells"},{"subitem_title":"p-Coumaric Acid Has Protective Effects against Mutant Copper–Zinc Superoxide Dismutase 1 via the Activation of Autophagy in N2a Cells","subitem_title_language":"en"}]},"item_type_id":"3","owner":"78","path":["300"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-03"},"publish_date":"2020-03-03","publish_status":"0","recid":"13707","relation_version_is_last":true,"title":["p-Coumaric Acid Has Protective Effects against Mutant Copper–Zinc Superoxide Dismutase 1 via the Activation of Autophagy in N2a Cells"],"weko_creator_id":"78","weko_shared_id":-1},"updated":"2023-06-19T07:50:07.728209+00:00"}