{"created":"2023-06-19T07:25:41.369824+00:00","id":13711,"links":{},"metadata":{"_buckets":{"deposit":"2d77ec6b-46b2-4aaa-bbbf-b81e0b2f8581"},"_deposit":{"created_by":78,"id":"13711","owners":[78],"pid":{"revision_id":0,"type":"depid","value":"13711"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00013711","sets":["212:264:299"]},"author_link":["29013"],"item_4_biblio_info_3":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"66","bibliographicPageStart":"59","bibliographicVolumeNumber":"71","bibliographic_titles":[{"bibliographic_title":"Brain Nerve"},{"bibliographic_title":"Brain Nerve","bibliographic_titleLang":"en"}]}]},"item_4_text_4":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_text_value":"10.11477/mf.1416201217"}]},"item_4_textarea_2":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_textarea_value":"特発性基底核石灰化症（IBGC）は原発性に脳内石灰化をきたす疾患である。その原因遺伝子としてSLC20A2，PDGFRB，PDGFB，XPR1，MYORGの5つが報告された。遺伝子変異から推定される病態機序は細胞内外における無機リン酸（Pi）の輸送の障害である。われわれはIBGC患者，特にSLC20A2遺伝子変異を認めるIBGC患者の脳脊髄液（CSF）中のPiが高値であることを報告した。CSFと脳組織間液の流通，また血管周囲腔を介した流路は，IBGCにおけるmineralizationの分布，病態をよく説明し得る。"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"特発性基底核石灰化症の病態解明の進歩","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"特発性基底核石灰化症の病態解明の進歩"},{"subitem_title":"Progress on the Pathophysiology of Idiopathic Basal Ganglia Calcification","subitem_title_language":"en"}]},"item_type_id":"4","owner":"78","path":["299"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-03"},"publish_date":"2020-03-03","publish_status":"0","recid":"13711","relation_version_is_last":true,"title":["特発性基底核石灰化症の病態解明の進歩"],"weko_creator_id":"78","weko_shared_id":-1},"updated":"2023-06-19T07:50:03.411567+00:00"}