{"created":"2023-06-19T07:25:42.684659+00:00","id":13744,"links":{},"metadata":{"_buckets":{"deposit":"44a1ad49-0c84-41e6-980a-3061961588ff"},"_deposit":{"created_by":79,"id":"13744","owners":[79],"pid":{"revision_id":0,"type":"depid","value":"13744"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00013744","sets":["212:260:312"]},"author_link":["29333","29335","29336","29332","29334"],"item_3_biblio_info_3":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5/6","bibliographicPageEnd":"111","bibliographicPageStart":"105","bibliographicVolumeNumber":"97","bibliographic_titles":[{},{"bibliographic_title":"Pharmacometrics","bibliographic_titleLang":"en"}]}]},"item_3_textarea_2":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_textarea_value":"Food thickening agents are used for easy taking medicines by patients with dysphagia. However, food thickening agents sometimes affect disintegration time and dissolution rate of medicines. Patients can select various beverages to dissolve food thickening agents. However, in the studies, water has been mainly used as a solvent. Although it has been reported that different solvents change physical properties of food thickening agents such as viscosity and adhesiveness, effects of the food thickening agents dissolved by the solvents on the disintegration and dissolution of tablets are poorly understood. We investigated effects of five solvents (soft water, hard water, milk, orange juice, and miso soup) used for preparing xanthan gum-based food thickening agent on the disintegration and dissolution of orally disintegrating levofloxacin (L-OD) tablets. The results of the test with the first fluid (pH 1.2) revealed that the disintegration time of L-OD immersed in the food thickener solution prepared with milk was the longest and the dissolution rate was the lowest. On the other hand, the results of second fluid (pH 6.8) showed that the disintegration time of L-OD immersed in the food thickener solution prepared with hard water and the dissolution rate was the lowest. The disintegration and dissolution of L-OD tablets differed depending on the solvent used to prepare the food thickener solution. These results suggest that the selection of solvents to dissolve food thickening agents is important for appropriate taking medicines in patients with dysphagia."}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"disintegration test","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dissolution test","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"food thickening agent","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"levofloxacin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"orally disintegrating tablet","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of Solvents Used for the Preparation of Food Thickening Agent on the Disintegration Time and Dissolution Rate of Orally Disintegrating Levofloxacin Tablets","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Solvents Used for the Preparation of Food Thickening Agent on the Disintegration Time and Dissolution Rate of Orally Disintegrating Levofloxacin Tablets","subitem_title_language":"en"}]},"item_type_id":"3","owner":"79","path":["312"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-04"},"publish_date":"2020-03-04","publish_status":"0","recid":"13744","relation_version_is_last":true,"title":["Effects of Solvents Used for the Preparation of Food Thickening Agent on the Disintegration Time and Dissolution Rate of Orally Disintegrating Levofloxacin Tablets"],"weko_creator_id":"79","weko_shared_id":-1},"updated":"2023-06-19T07:49:48.271884+00:00"}