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Human β-defensin-2 as a biochemical indicator of vaginal environment in pregnant women
https://gifu-pu.repo.nii.ac.jp/records/13746
https://gifu-pu.repo.nii.ac.jp/records/13746bd95218f-6311-4f0d-ae32-3b1d369920df
| Item type | 研究室原著論文(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-03-04 | |||||
| タイトル | ||||||
| タイトル | Human β-defensin-2 as a biochemical indicator of vaginal environment in pregnant women | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | bacterial vaginosis | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | human β-defensin-2 | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | premature rupture of the membranes | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | vaginal candidiasis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 抄録 | ||||||
| 値 | Aim: Vaginal environment is an important factor in predicting threatened abortion and premature rupture of membranes (PROM) in early pregnancy. Vaginal human β-defensin-2 (HBD-2), a main antimicrobial peptide associated with innate immunity, plays multiple roles to protect the lower genital tract from microbes. This study aimed to assess the usefulness of vaginal HBD-2 as a biochemical marker for monitoring the vaginal environment in pregnant women. Methods: Twenty-eight pregnant women were enrolled in this study. Vaginal secretion samples were collected to determine Nugent scores, and vaginal washing fluid (4 ml saline) was used to measure HBD-2 levels by ELISA. Results: In the first trimester, vaginal HBD-2 levels were significantly lower in patients with bacterial vaginosis (BV) (42.1±19.8 pg/ml) compared to those without BV (350.1±68.7 pg/ml, P<0.05), and in patients with PROM (57.2±31.9 pg/ml) compared to those without PROM (375.9±69.4 pg/ml, P<0.05). Conclusions: Low vaginal HBD-2 levels during early pregnancy suggest a poor vaginal environment and the possibility of developing PROM. |
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| 書誌情報 |
en : Hypertension Reserch in Pregnancy 巻 6, 号 2, p. 68-72, 発行日 2018 |
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| DOI | ||||||
| 値 | 10.14390/jsshp.HRP2018-005 | |||||
