{"created":"2023-06-19T07:25:42.768804+00:00","id":13746,"links":{},"metadata":{"_buckets":{"deposit":"e2348998-c360-40de-9e89-ef334c33755c"},"_deposit":{"created_by":40,"id":"13746","owners":[40],"pid":{"revision_id":0,"type":"depid","value":"13746"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00013746","sets":["212:271:294"]},"author_link":["29345","29347","29348","29341","29342","29343","29344","29346"],"item_3_biblio_info_3":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"72","bibliographicPageStart":"68","bibliographicVolumeNumber":"6","bibliographic_titles":[{},{"bibliographic_title":"Hypertension Reserch in Pregnancy","bibliographic_titleLang":"en"}]}]},"item_3_text_4":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_text_value":"10.14390/jsshp.HRP2018-005"}]},"item_3_textarea_2":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_textarea_value":"Aim: Vaginal environment is an important factor in predicting threatened abortion and premature rupture of membranes (PROM) in early pregnancy. Vaginal human β-defensin-2 (HBD-2), a main antimicrobial peptide associated with innate immunity, plays multiple roles to protect the lower genital tract from microbes. This study aimed to assess the usefulness of vaginal HBD-2 as a biochemical marker for monitoring the vaginal environment in pregnant women.\n\nMethods: Twenty-eight pregnant women were enrolled in this study. Vaginal secretion samples were collected to determine Nugent scores, and vaginal washing fluid (4 ml saline) was used to measure HBD-2 levels by ELISA.\n\nResults: In the first trimester, vaginal HBD-2 levels were significantly lower in patients with bacterial vaginosis (BV) (42.1±19.8 pg/ml) compared to those without BV (350.1±68.7 pg/ml, P<0.05), and in patients with PROM (57.2±31.9 pg/ml) compared to those without PROM (375.9±69.4 pg/ml, P<0.05).\n\nConclusions: Low vaginal HBD-2 levels during early pregnancy suggest a poor vaginal environment and the possibility of developing PROM."}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"bacterial vaginosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"human β-defensin-2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"premature rupture of the membranes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"vaginal candidiasis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Human β-defensin-2 as a biochemical indicator of vaginal environment in pregnant women","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Human β-defensin-2 as a biochemical indicator of vaginal environment in pregnant women","subitem_title_language":"en"}]},"item_type_id":"3","owner":"40","path":["294"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-04"},"publish_date":"2020-03-04","publish_status":"0","recid":"13746","relation_version_is_last":true,"title":["Human β-defensin-2 as a biochemical indicator of vaginal environment in pregnant women"],"weko_creator_id":"40","weko_shared_id":-1},"updated":"2023-06-19T07:49:44.789021+00:00"}