{"created":"2023-06-19T07:25:52.452177+00:00","id":14007,"links":{},"metadata":{"_buckets":{"deposit":"5713dcb8-873a-49d6-9d9e-379337af6017"},"_deposit":{"created_by":57,"id":"14007","owners":[57],"pid":{"revision_id":0,"type":"depid","value":"14007"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00014007","sets":["212:265:270"]},"author_link":["31163","31162","31168","31155","31157","31164","31154","31159","31160","31165","31166","31158","31161","31169","31167","31156"],"item_3_biblio_info_3":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicVolumeNumber":"11","bibliographic_titles":[{},{"bibliographic_title":"Nature Communications","bibliographic_titleLang":"en"}]}]},"item_3_text_4":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_text_value":"10.1038/s41467-020-17636-0"}]},"item_3_textarea_2":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_textarea_value":"Supercentenarians (those aged ≥110 years) are approaching the current human longevity limit by preventing or surviving major illness. Identifying specific biomarkers conducive to exceptional survival might provide insights into counter-regulatory mechanisms against aging-related disease. Here, we report associations between cardiovascular disease-related biomarkers and survival to the highest ages using a unique dataset of 1,427 oldest individuals from three longitudinal cohort studies, including 36 supercentenarians, 572 semi-supercentenarians (105-109 years), 288 centenarians (100-104 years), and 531 very old people (85-99 years). During follow-up, 1,000 participants (70.1%) died. Overall, N-terminal pro-B-type natriuretic peptide (NT-proBNP), interleukin-6, cystatin C and cholinesterase are associated with all-cause mortality independent of traditional cardiovascular risk factors and plasma albumin. Of these, low NT-proBNP levels are statistically associated with a survival advantage to supercentenarian age. Only low albumin is associated with high mortality across age groups. These findings expand our knowledge on the biology of human longevity."}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages"}]},"item_type_id":"3","owner":"57","path":["270"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-09-08"},"publish_date":"2020-09-08","publish_status":"0","recid":"14007","relation_version_is_last":true,"title":["Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages"],"weko_creator_id":"57","weko_shared_id":-1},"updated":"2023-06-19T07:47:11.451379+00:00"}