{"created":"2023-06-19T07:25:53.917700+00:00","id":14043,"links":{},"metadata":{"_buckets":{"deposit":"4f9e72ab-713d-49b8-bc2a-2b2c998c82ce"},"_deposit":{"created_by":95,"id":"14043","owners":[95],"pid":{"revision_id":0,"type":"depid","value":"14043"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00014043","sets":["212:264:300"]},"author_link":["31318","31316","31321","31317","31322","31320","31319"],"item_3_biblio_info_3":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-08-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"20","bibliographicPageStart":"30077-3","bibliographicVolumeNumber":"S1347-8613","bibliographic_titles":[{"bibliographic_title":"Journal of Pharmacological Sciences"},{"bibliographic_title":"Journal of Pharmacological Sciences","bibliographic_titleLang":"en"}]}]},"item_3_text_4":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_text_value":"10.1016/j.jphs.2020.07.012."}]},"item_3_textarea_2":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_textarea_value":"Oxidative stress is associated with the progression of the neurodegenerative diseases Parkinson's disease (PD) and cerebral ischemia. Recently, 5-aminolevulinic acid (5-ALA), an intermediate in the porphyrin synthesis pathway, was reported to exert antioxidative effects on macrophages and cardiomyocytes. Here, we demonstrated the neuroprotective effects of 5-ALA using rat models of PD and ischemia as well as in vitro in SH-SY5Y cells. 5-ALA partially prevented neurodegeneration in each condition. These results suggest that 5-ALA has a potential for promising therapeutic agent to protect against neurodegeneration exacerbated by oxidative stress."}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Neuroprotective effects of 5-aminolevulinic acid against neurodegeneration in rat models of Parkinson's disease and stroke","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Neuroprotective effects of 5-aminolevulinic acid against neurodegeneration in rat models of Parkinson's disease and stroke"},{"subitem_title":"Neuroprotective effects of 5-aminolevulinic acid against neurodegeneration in rat models of Parkinson's disease and stroke","subitem_title_language":"en"}]},"item_type_id":"3","owner":"95","path":["300"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-09-08"},"publish_date":"2020-09-08","publish_status":"0","recid":"14043","relation_version_is_last":true,"title":["Neuroprotective effects of 5-aminolevulinic acid against neurodegeneration in rat models of Parkinson's disease and stroke"],"weko_creator_id":"95","weko_shared_id":-1},"updated":"2023-06-19T07:46:52.620943+00:00"}