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  1. 教員研究業績
  2. 薬品物理化学研究室
  3. 原著論文

Photo-responsive polymer micelles from o-nitrobenzyl ester-based amphiphilic block copolymers synthesized by mechanochemical solid-state copolymerization

https://gifu-pu.repo.nii.ac.jp/records/14093
https://gifu-pu.repo.nii.ac.jp/records/14093
62ab3313-1221-413c-adec-7bfd7400ca9b
Item type 研究室原著論文(1)
公開日 2020-09-10
タイトル
タイトル Photo-responsive polymer micelles from o-nitrobenzyl ester-based amphiphilic block copolymers synthesized by mechanochemical solid-state copolymerization
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
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アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
抄録
値 Polymer micelles with a tunable drug release would be suitable for the concept of drug delivery system. We constructed photo-responsive polymer micelles from amphiphilic block copolymers. The polymer micelles were synthesized by mechanochemical solid-state copolymerization of poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) and 4,5-dimethoxy-2-nitrobenzyl methacrylate as a photosensitive moiety. The above mechanochemical solid-state copolymerization was performed by vibratory-ball milling at 30 Hz in a nitrogen atmosphere with the use of an agate vessel and an agate ball to yield amphiphilic block copolymers (PHPMA-b-PDNMA). Spherical polymer micelles were formed by the self-assembly of PHPMA-b-PDNMA. The diameter of the PHPMA-b-PDNMA micelles was in the range of 130-200 nm. The PHPMA-b-PDNMA micelles loaded with the antitumor drug 5-fluorouracil (5-FU) showed photo irradiation induced time-dependent release of 5-FU with an associated decrease of micellar size. The drug release profile of the PHPMA-b-PDNMA micelles followed a clear sigmoid curve. Our approach provides a controlled drug release system through the use of photo-responsive polymer micelles, accompanied by the gradual decrease of micellar size.
書誌情報 en : Polymer Journal

発行日 2020-07-31
DOI
値 10.1038/s41428-020-0387-9
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