{"created":"2023-06-19T07:25:55.659701+00:00","id":14093,"links":{},"metadata":{"_buckets":{"deposit":"3604c771-fdb9-4b3f-b1ce-f0657948de6a"},"_deposit":{"created_by":102,"id":"14093","owners":[102],"pid":{"revision_id":0,"type":"depid","value":"14093"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00014093","sets":["212:254:330"]},"author_link":["31694","31690","18586","31693","31689","31695"],"item_3_biblio_info_3":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-07-31","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{},{"bibliographic_title":"Polymer Journal","bibliographic_titleLang":"en"}]}]},"item_3_text_4":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_text_value":"10.1038/s41428-020-0387-9"}]},"item_3_textarea_2":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_textarea_value":"Polymer micelles with a tunable drug release would be suitable for the concept of drug delivery system. We constructed photo-responsive polymer micelles from amphiphilic block copolymers. The polymer micelles were synthesized by mechanochemical solid-state copolymerization of poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) and 4,5-dimethoxy-2-nitrobenzyl methacrylate as a photosensitive moiety. The above mechanochemical solid-state copolymerization was performed by vibratory-ball milling at 30 Hz in a nitrogen atmosphere with the use of an agate vessel and an agate ball to yield amphiphilic block copolymers (PHPMA-b-PDNMA). Spherical polymer micelles were formed by the self-assembly of PHPMA-b-PDNMA. The diameter of the PHPMA-b-PDNMA micelles was in the range of 130-200 nm. The PHPMA-b-PDNMA micelles loaded with the antitumor drug 5-fluorouracil (5-FU) showed photo irradiation induced time-dependent release of 5-FU with an associated decrease of micellar size. The drug release profile of the PHPMA-b-PDNMA micelles followed a clear sigmoid curve. Our approach provides a controlled drug release system through the use of photo-responsive polymer micelles, accompanied by the gradual decrease of micellar size."}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Photo-responsive polymer micelles from o-nitrobenzyl ester-based amphiphilic block copolymers synthesized by mechanochemical solid-state copolymerization","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Photo-responsive polymer micelles from o-nitrobenzyl ester-based amphiphilic block copolymers synthesized by mechanochemical solid-state copolymerization","subitem_title_language":"en"}]},"item_type_id":"3","owner":"102","path":["330"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-09-10"},"publish_date":"2020-09-10","publish_status":"0","recid":"14093","relation_version_is_last":true,"title":["Photo-responsive polymer micelles from o-nitrobenzyl ester-based amphiphilic block copolymers synthesized by mechanochemical solid-state copolymerization"],"weko_creator_id":"102","weko_shared_id":-1},"updated":"2023-06-19T07:46:22.946268+00:00"}