{"created":"2023-06-19T07:25:55.702044+00:00","id":14094,"links":{},"metadata":{"_buckets":{"deposit":"223a2b8e-8ff3-40c4-93e0-89ca215b9704"},"_deposit":{"created_by":102,"id":"14094","owners":[102],"pid":{"revision_id":0,"type":"depid","value":"14094"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00014094","sets":["212:254:330"]},"author_link":["31697","31690","31688","31696","31698"],"item_3_biblio_info_3":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-07-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"348","bibliographicPageStart":"343","bibliographicVolumeNumber":"33","bibliographic_titles":[{},{"bibliographic_title":"Journal of Photopolymer Science and Technology","bibliographic_titleLang":"en"}]}]},"item_3_text_4":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_text_value":"10.2494/photopolymer.33.343"}]},"item_3_textarea_2":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_textarea_value":"A crystalline acrylic-type polymerizable monomer of Nalidixic acid (NA) was synthesized by linking NA molecule to acrylic acid (AA) via acid-anhydride conjugate. Then, the monomer was polymerized in solid state by vibratory mixing with plasma-irradiated lactose powders as postprocessing-free initiators. The characterization of the resulting polymeric prodrug powders by ESR, XRPD and FT-IR analysis confirmed their synthesis successfully. The in vitro hydrolysis study of the polymeric prodrugs was carried out in three different buffer solutions at 37 ℃. The results indicated that the acid-anhydride conjugate of the polymeric prodrugs was relatively stable to acid-catalyzed hydrolysis, and the NA release was in sustained manner with no burst and enhanced in basic media, in which ca. 4%, 35% and 80% of NA was released in 12 h at pH 1.2, pH 6.8 and pH 8.5, respectively. The obtained results suggested that the studied systems could be potential antibacterial polymeric prodrugs to minimize drug-stomach exposure and to use for colonic-targeting drug delivery formulation."}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Plasma irradiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug delivery system","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Antibacterial agent","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Polymeric prodrugs","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Synthesis and Characterization of Polymer-Linked Prodrug of Antibacterial Agent for The Targeted Delivery to The Colon by Cold Plasma Technique","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Synthesis and Characterization of Polymer-Linked Prodrug of Antibacterial Agent for The Targeted Delivery to The Colon by Cold Plasma Technique","subitem_title_language":"en"}]},"item_type_id":"3","owner":"102","path":["330"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-09-10"},"publish_date":"2020-09-10","publish_status":"0","recid":"14094","relation_version_is_last":true,"title":["Synthesis and Characterization of Polymer-Linked Prodrug of Antibacterial Agent for The Targeted Delivery to The Colon by Cold Plasma Technique"],"weko_creator_id":"102","weko_shared_id":-1},"updated":"2023-06-19T07:46:23.961847+00:00"}