{"created":"2023-06-19T07:25:57.868862+00:00","id":14149,"links":{},"metadata":{"_buckets":{"deposit":"00e7aac3-d1a1-4ec0-bff3-8087c3a4d077"},"_deposit":{"created_by":106,"id":"14149","owners":[106],"pid":{"revision_id":0,"type":"depid","value":"14149"},"status":"published"},"_oai":{"id":"oai:gifu-pu.repo.nii.ac.jp:00014149","sets":["212:255:327"]},"author_link":["32114","32115","32110","32112","32111","32109","32113"],"item_3_biblio_info_3":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-19","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"33","bibliographicPageStart":"18","bibliographicVolumeNumber":"17","bibliographic_titles":[{},{"bibliographic_title":"Journal of Nutritional Food","bibliographic_titleLang":"en"}]}]},"item_3_text_4":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_text_value":"10.20618/jhnfa.17.1_18"}]},"item_3_textarea_2":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_textarea_value":"The cornea is located on the surface of the eyeball and is constantly activated with light and various physical stimuli. Humans\nare exposed to UV and other light with various wavelengths during daily life. Light ranging from 380 nm to 530 nm comprises\nhigh-energy visible light that is present in sunlight, fluorescent light, and light-emitting diodes (LEDs). In this report,\nwe investigated the effects of bilberry extract and its anthocyanin constituents on corneal epithelial cell damage induced by\nblue LED light. Human corneal epithelial (HCE-T) cells were in the presence of bilberry extract or its anthocyanin constituents\nfollowed by exposure to 2,000 lux of blue LED light. We found that bilberry extract or its anthocyanin constituents (delphinidin\n3-glucoside and cyanidin 3-glucoside) reduced cell death, reactive oxygen species (ROS) production and cell dehydrogenase\nactivity. In addition, bilberry extract inhibited blue LED light-induced changes in the mitochondrial membrane potential\nand caspase-3/7 activity, both of which are associated with apoptosis. These findings suggested that bilberry extract or its\nconstituent anthocyanins have protective effects against blue LED light-induced cell damage by reducing ROS production.\nKey words: blue light-emitting diode light, corneal epithelial cells, reactive oxygen species, bilberry, anthocyanin"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The protective effects of bilberry extract and its main constituents against blue light-emitting diode (LED) light-induced damage in human corneal epithelial cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The protective effects of bilberry extract and its main constituents against blue light-emitting diode (LED) light-induced damage in human corneal epithelial cells","subitem_title_language":"en"}]},"item_type_id":"3","owner":"106","path":["327"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-09-11"},"publish_date":"2020-09-11","publish_status":"0","recid":"14149","relation_version_is_last":true,"title":["The protective effects of bilberry extract and its main constituents against blue light-emitting diode (LED) light-induced damage in human corneal epithelial cells"],"weko_creator_id":"106","weko_shared_id":-1},"updated":"2023-06-19T07:45:48.107639+00:00"}