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Revisiting the synthesis of aryl nitriles: a pivotal role of CAN
https://gifu-pu.repo.nii.ac.jp/records/14238
https://gifu-pu.repo.nii.ac.jp/records/142381f005f8c-e1f7-4a83-9306-b6f87ea10b24
| Item type | 研究室原著論文(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-03-03 | |||||
| タイトル | ||||||
| タイトル | Revisiting the synthesis of aryl nitriles: a pivotal role of CAN | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 抄録 | ||||||
| 値 | Facilitated by the dual role of Ceric Ammonium Nitrate (CAN), herein we report a cost-effective approach for the cyanation of aryl iodides/bromides with CAN–DMF as an addition to the existing pool of combined cyanation sources. In addition to being an oxidant, CAN acts as a source of nitrogen in our protocol. The reaction is catalyzed by a readily available Cu(II) salt and the ability of CAN to generate ammonia in the reaction medium is utilized to eliminate the additional requirement of a nitrogen source, ligand, additive or toxic reagents. The mechanistic study suggests an evolution of CN− leading to the synthesis of a variety of aryl nitriles in moderate to good yields. The proposed mechanism is supported by a series of control reactions and labeling experiments. | |||||
| 書誌情報 |
en : Organic & Biomolecular Chemistry 巻 19, 号 6, p. 1344-1351, 発行日 2021-01-06 |
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| DOI | ||||||
| 値 | 10.1039/D0OB02518F | |||||
