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Moesin is involved in microglial activation accompanying morphological changes and reorganization of the actin cytoskeleton.
https://gifu-pu.repo.nii.ac.jp/records/14270
https://gifu-pu.repo.nii.ac.jp/records/1427007441dad-8cbf-4ad2-8584-7f012eccbf50
| Item type | 研究室原著論文(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-03-04 | |||||
| タイトル | ||||||
| タイトル | Moesin is involved in microglial activation accompanying morphological changes and reorganization of the actin cytoskeleton. | |||||
| タイトル | ||||||
| タイトル | Moesin is involved in microglial activation accompanying morphological changes and reorganization of the actin cytoskeleton. | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 抄録 | ||||||
| 値 | Moesin is a member of the ezrin, radixin and moesin (ERM) proteins that are involved in the formation and/or maintenance of cortical actin organization through their cross-linking activity between actin filaments and proteins located on the plasma membranes as well as through regulation of small GTPase activities. Microglia, immune cells in the central nervous system, show dynamic reorganization of the actin cytoskeleton in their process elongation and retraction as well as phagocytosis and migration. In microglia, moesin is the predominant ERM protein. Here, we show that microglial activation after systemic lipopolysaccharide application is partly inhibited in moesin knockout (Msn-KO) mice. We prepared primary microglia from wild-type and Msn-KO mice, and studied them to compare their phenotypes accompanying morphological changes and reorganization of the actin cytoskeleton induced by UDP-stimulated phagocytosis and ADP-stimulated migration. The Msn-KO microglia showed higher phagocytotic activity in the absence of UDP, which was not further increased by the treatment with UDP. They also exhibited decreased ADP-stimulated migration activities compared with the wild-type microglia. However, the Msn-KO microglia retained their ability to secrete tumor necrosis factor α and nitric oxide in response to lipopolysaccharide. | |||||
| 書誌情報 |
en : The journal of physiological sciences : JPS 巻 70, 号 1, p. 52, 発行日 2020-10-31 |
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| DOI | ||||||
| 値 | 10.1186/s12576-020-00779-6 | |||||
